Serum levels of virus burden in early-stage human immunodeficiency virus type 1 disease in women

James S. Evans, Theresa Nims, John Cooley, William Bradley, Linda Jagodzinski, Susan Zhou, Gregory P. Melcher, Donald S. Burke, Maryanne Vahey

Research output: Contribution to journalArticle

Abstract

The fundamental clinical, viral, and immunologic features of early- stage human immunodeficiency virus type 1 (HIV-1) disease were examined in a seroprevalent cohort of 28 men and 14 women assessed longitudinally at three equally dispersed time points over a mean of 43 months. There were no gender differences in the relative risk of developing AIDS-defining end points or death. The median serum RNA levels assessed at the three study time points were 3.3-, 4.9-, and 1.5-fold lower, respectively, in women than in men. This suggests that while serum virus load may be as powerful a correlate of disease status in women as it is in men, the absolute values of the virus levels may be different in the 2 populations. These observations may have implications for the interpretation of levels of virus burden in women for the assessment of disease progression, transmission, and treatment.

Original languageEnglish (US)
Pages (from-to)795-800
Number of pages6
JournalJournal of Infectious Diseases
Volume175
Issue number4
StatePublished - 1997
Externally publishedYes

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Virus Diseases
HIV-1
Viruses
Serum
Women's Rights
Disease Progression
Acquired Immunodeficiency Syndrome
RNA
Population
Therapeutics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Evans, J. S., Nims, T., Cooley, J., Bradley, W., Jagodzinski, L., Zhou, S., ... Vahey, M. (1997). Serum levels of virus burden in early-stage human immunodeficiency virus type 1 disease in women. Journal of Infectious Diseases, 175(4), 795-800.

Serum levels of virus burden in early-stage human immunodeficiency virus type 1 disease in women. / Evans, James S.; Nims, Theresa; Cooley, John; Bradley, William; Jagodzinski, Linda; Zhou, Susan; Melcher, Gregory P.; Burke, Donald S.; Vahey, Maryanne.

In: Journal of Infectious Diseases, Vol. 175, No. 4, 1997, p. 795-800.

Research output: Contribution to journalArticle

Evans, JS, Nims, T, Cooley, J, Bradley, W, Jagodzinski, L, Zhou, S, Melcher, GP, Burke, DS & Vahey, M 1997, 'Serum levels of virus burden in early-stage human immunodeficiency virus type 1 disease in women', Journal of Infectious Diseases, vol. 175, no. 4, pp. 795-800.
Evans JS, Nims T, Cooley J, Bradley W, Jagodzinski L, Zhou S et al. Serum levels of virus burden in early-stage human immunodeficiency virus type 1 disease in women. Journal of Infectious Diseases. 1997;175(4):795-800.
Evans, James S. ; Nims, Theresa ; Cooley, John ; Bradley, William ; Jagodzinski, Linda ; Zhou, Susan ; Melcher, Gregory P. ; Burke, Donald S. ; Vahey, Maryanne. / Serum levels of virus burden in early-stage human immunodeficiency virus type 1 disease in women. In: Journal of Infectious Diseases. 1997 ; Vol. 175, No. 4. pp. 795-800.
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