Serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations

Helena M. Calil; David H. Avery; Leo E. Hollister; Ian Creese; Solomon H. Snyder

doi:10.1016/0165-1781(79)90026-X

Serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations

Helena M. Calil, David H. Avery, Leo E. Hollister, Ian Creese, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridazine or mesoridazine. No detectable serum levels were found in 11 patients, probably either due to low drug doses or noncompliance in taking medication. Best results with the assay were obtained in the 22 patients treated with haloperidol. Serum concentrations of haloperidol were correlated with dose and were related to the Brief Psychiatric Rating Scale (BPRS) total pathology score, as well as to BPRS factor scores for thinking disturbance and paranoid disturbance. Serum concentrations of haloperidol were not different among patients with or without the presence of extrapyramidal symptoms or among patients receiving or not receiving concurrent antiparkinson medication.

Original language	English (US)
Pages (from-to)	39-44
Number of pages	6
Journal	Psychiatry research
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(79)90026-X
State	Published - Jul 1979

Keywords

Neuroleptic serum levels
dopamine radioreceptor assay

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(79)90026-X

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abstract = "A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridazine or mesoridazine. No detectable serum levels were found in 11 patients, probably either due to low drug doses or noncompliance in taking medication. Best results with the assay were obtained in the 22 patients treated with haloperidol. Serum concentrations of haloperidol were correlated with dose and were related to the Brief Psychiatric Rating Scale (BPRS) total pathology score, as well as to BPRS factor scores for thinking disturbance and paranoid disturbance. Serum concentrations of haloperidol were not different among patients with or without the presence of extrapyramidal symptoms or among patients receiving or not receiving concurrent antiparkinson medication.",

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AU - Creese, Ian

AU - Snyder, Solomon H.

PY - 1979/7

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N2 - A new dopamine radioreceptor assay was used to measure serum concentrations of neuroleptics during treatment of 58 patients. Results of this assay are expressed as chlorpromazine equivalents. Serum concentrations varied with different drugs, with extremely high levels in patients receiving thioridazine or mesoridazine. No detectable serum levels were found in 11 patients, probably either due to low drug doses or noncompliance in taking medication. Best results with the assay were obtained in the 22 patients treated with haloperidol. Serum concentrations of haloperidol were correlated with dose and were related to the Brief Psychiatric Rating Scale (BPRS) total pathology score, as well as to BPRS factor scores for thinking disturbance and paranoid disturbance. Serum concentrations of haloperidol were not different among patients with or without the presence of extrapyramidal symptoms or among patients receiving or not receiving concurrent antiparkinson medication.

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Serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations

Abstract

Keywords

ASJC Scopus subject areas

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