Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty

Sean Leng, Anne R. Cappola, Ross E. Andersen, Marc R. Blackman, Kathleen Koenig, Michael Blair, Jeremy D Walston

Research output: Contribution to journalArticle

Abstract

Background and aims: The geriatric syndrome of frailty has been conceptualized as a loss of physiologic reserve associated with endocrine dysregulation and immune dysfunction. Our prior studies suggest that the frailty syndrome is associated with elevated serum IL-6 levels. In the present study, our aim is to evaluate the possible role of endocrine dysregulation and its relationship with serum IL-6 in the pathogenesis of this syndrome. Methods: Using a recently validated screening algorithm for frailty, we identified 18 frail and 33 non-frail community-dwelling older adults for inclusion in this study. Serum levels of insulin-like growth factor-I (IGF-I), DHEA-S, and IL-6 were measured by immunoassays. The inter-relationships among serum levels of IL-6, DHEA-S, and IGF-I were determined by linear regression analysis. Results: Age-adjusted serum levels of IGF-I (88±49 vs 122± 47 [ng/mL], p

Original languageEnglish (US)
Pages (from-to)153-157
Number of pages5
JournalAging clinical and experimental research
Volume16
Issue number2
StatePublished - Apr 2004

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Dehydroepiandrosterone Sulfate
Insulin-Like Growth Factor I
Geriatrics
Interleukin-6
Serum
Independent Living
Immunoassay
Linear Models
Regression Analysis

Keywords

  • DHEA-S
  • Endocrine correlates of frailty
  • Geriatric syndrome
  • IGF-I
  • IL-6
  • Primary frailty

ASJC Scopus subject areas

  • Aging

Cite this

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title = "Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty",
abstract = "Background and aims: The geriatric syndrome of frailty has been conceptualized as a loss of physiologic reserve associated with endocrine dysregulation and immune dysfunction. Our prior studies suggest that the frailty syndrome is associated with elevated serum IL-6 levels. In the present study, our aim is to evaluate the possible role of endocrine dysregulation and its relationship with serum IL-6 in the pathogenesis of this syndrome. Methods: Using a recently validated screening algorithm for frailty, we identified 18 frail and 33 non-frail community-dwelling older adults for inclusion in this study. Serum levels of insulin-like growth factor-I (IGF-I), DHEA-S, and IL-6 were measured by immunoassays. The inter-relationships among serum levels of IL-6, DHEA-S, and IGF-I were determined by linear regression analysis. Results: Age-adjusted serum levels of IGF-I (88±49 vs 122± 47 [ng/mL], p",
keywords = "DHEA-S, Endocrine correlates of frailty, Geriatric syndrome, IGF-I, IL-6, Primary frailty",
author = "Sean Leng and Cappola, {Anne R.} and Andersen, {Ross E.} and Blackman, {Marc R.} and Kathleen Koenig and Michael Blair and Walston, {Jeremy D}",
year = "2004",
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AU - Cappola, Anne R.

AU - Andersen, Ross E.

AU - Blackman, Marc R.

AU - Koenig, Kathleen

AU - Blair, Michael

AU - Walston, Jeremy D

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