Serum levels of cytokines and biomarkers for inflammation and immune activation, and HIV-Associated non-hodgkin B-Cell lymphoma risk

Elena Vendrame, Shehnaz K. Hussain, Elizabeth Crabb Breen, Larry I. Magpantay, Daniel P. Widney, Lisa P. Jacobson, Daina Variakojis, Emilee R. Knowlton, Jay H. Bream, Richard F. Ambinder, Roger Detels, Otoniel Mart́nez-Maza

Research output: Contribution to journalArticlepeer-review

Abstract

Background: HIV infection is associated with a marked increase in risk for non-Hodgkin lymphoma (AIDSNHL). However, the mechanisms that promote the development of AIDS-NHL are not fully understood. Methods: In this study, serum levels of several cytokines and other molecules associated with immune activation were measured in specimens collected longitudinally during 1 to 5 years preceding AIDS-NHL diagnosis, in 176 AIDS-NHL cases and 176 HIV{thorn} controls from the Multicenter AIDS Cohort Study (MACS). Results: Multivariate analyses revealed that serum levels of immunoglobulin free light chains (FLC), interleukin (IL)-6, IL-10, IP-10/CXCL10, neopterin, and TNF-A were elevated in those HIV{thorn} individuals who went on to develop AIDS-NHL. In addition, the fraction of specimens with detectable IL-2 was increased and the fraction with detectable IL-4 was decreased in these subjects. Conclusions: These results suggest that long-term, chronic immune activation, possibly driven by macrophage- produced cytokines, precedes development of NHL in HIV{thorn} individuals. Impact: FLC, IL-6, IL-10, IP-10/CXCL10, neopterin, and TNF-A may serve as biomarkers for AIDS-NHL.

Original languageEnglish (US)
Pages (from-to)343-349
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume23
Issue number2
DOIs
StatePublished - Feb 2014

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Fingerprint Dive into the research topics of 'Serum levels of cytokines and biomarkers for inflammation and immune activation, and HIV-Associated non-hodgkin B-Cell lymphoma risk'. Together they form a unique fingerprint.

Cite this