TY - JOUR
T1 - Serum levels of cytokines and biomarkers for inflammation and immune activation, and HIV-Associated non-hodgkin B-Cell lymphoma risk
AU - Vendrame, Elena
AU - Hussain, Shehnaz K.
AU - Breen, Elizabeth Crabb
AU - Magpantay, Larry I.
AU - Widney, Daniel P.
AU - Jacobson, Lisa P.
AU - Variakojis, Daina
AU - Knowlton, Emilee R.
AU - Bream, Jay H.
AU - Ambinder, Richard F.
AU - Detels, Roger
AU - Mart́nez-Maza, Otoniel
PY - 2014/2
Y1 - 2014/2
N2 - Background: HIV infection is associated with a marked increase in risk for non-Hodgkin lymphoma (AIDSNHL). However, the mechanisms that promote the development of AIDS-NHL are not fully understood. Methods: In this study, serum levels of several cytokines and other molecules associated with immune activation were measured in specimens collected longitudinally during 1 to 5 years preceding AIDS-NHL diagnosis, in 176 AIDS-NHL cases and 176 HIV{thorn} controls from the Multicenter AIDS Cohort Study (MACS). Results: Multivariate analyses revealed that serum levels of immunoglobulin free light chains (FLC), interleukin (IL)-6, IL-10, IP-10/CXCL10, neopterin, and TNF-A were elevated in those HIV{thorn} individuals who went on to develop AIDS-NHL. In addition, the fraction of specimens with detectable IL-2 was increased and the fraction with detectable IL-4 was decreased in these subjects. Conclusions: These results suggest that long-term, chronic immune activation, possibly driven by macrophage- produced cytokines, precedes development of NHL in HIV{thorn} individuals. Impact: FLC, IL-6, IL-10, IP-10/CXCL10, neopterin, and TNF-A may serve as biomarkers for AIDS-NHL.
AB - Background: HIV infection is associated with a marked increase in risk for non-Hodgkin lymphoma (AIDSNHL). However, the mechanisms that promote the development of AIDS-NHL are not fully understood. Methods: In this study, serum levels of several cytokines and other molecules associated with immune activation were measured in specimens collected longitudinally during 1 to 5 years preceding AIDS-NHL diagnosis, in 176 AIDS-NHL cases and 176 HIV{thorn} controls from the Multicenter AIDS Cohort Study (MACS). Results: Multivariate analyses revealed that serum levels of immunoglobulin free light chains (FLC), interleukin (IL)-6, IL-10, IP-10/CXCL10, neopterin, and TNF-A were elevated in those HIV{thorn} individuals who went on to develop AIDS-NHL. In addition, the fraction of specimens with detectable IL-2 was increased and the fraction with detectable IL-4 was decreased in these subjects. Conclusions: These results suggest that long-term, chronic immune activation, possibly driven by macrophage- produced cytokines, precedes development of NHL in HIV{thorn} individuals. Impact: FLC, IL-6, IL-10, IP-10/CXCL10, neopterin, and TNF-A may serve as biomarkers for AIDS-NHL.
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U2 - 10.1158/1055-9965.EPI-13-0714
DO - 10.1158/1055-9965.EPI-13-0714
M3 - Article
C2 - 24220912
AN - SCOPUS:84893658970
SN - 1055-9965
VL - 23
SP - 343
EP - 349
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 2
ER -