Serum immunoreactive erythropoietin in rheumatoid arthritis: impaired response to anemia

Marc C. Hochberg, Cynthia M. Arnold, Beth B. Hogans, Jerry L. Spivak

Research output: Contribution to journalArticle

Abstract

Serum immunoreactive erythropoietin (EP) levels were measured in 116 patients with rheumatoid arthritis (RA) and 20 control patients with iron deficiency anemia. Serum EP levels were significantly higher in the 46 anemic RA patients than in the 70 nonanemic RA patients (mean ± 1 SD 31.0 ± 19.8 mU/ml versus 16.8 ± 12.4 mU/ml; P < 0.0001). Furthermore, although a significant inverse correlation between the serum EP level and the hemoglobin value was present in the anemic RA patients (r = −0.57, P < 0.0001), the regression coefficient describing the relationship between serum EP and hemoglobin was significantly lower for the anemic RA patients than for patients with iron deficiency anemia (F = 6.01, P < 0.025).

Original languageEnglish (US)
Pages (from-to)1318-1321
Number of pages4
JournalArthritis & Rheumatism
Volume31
Issue number10
DOIs
StatePublished - Oct 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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