Serum immunoreactive erythropoietin in health and disease

Research output: Contribution to journalArticle

Abstract

Erythropoietin, the glycoprotein which regulates erythropoiesis is unique amongst the hematopoietic growth factors since it is the only one which behaves like a hormone. Produced primarily in the kidneys in adults, erythropoietin interacts with erythroid precursors in the marrow to increase red cell production. Because erythropoietin behaves like a hormone, measurements of erythropoietin in the serum have proved useful in determining when production of this hormone is inadequate. Tissue hypoxia is the only physiologic stimulus for erythropoietin production and thus, with anemia, serum erythropoietin levels should be increased. Assuming normal marrow function and adequate nutrient supplies, when anemia is associated with a low serum erythropoietin level, it can be concluded that the anemia is in part due to erythropoietin lack and should be correctable by administration of erythropoietin. As a corollary, a high serum erythropoietin level (greater than 500 mU/ml) in the presence of anemia suggests that there is end organ failure, and erythropoietin therapy is not likely to be useful.

Original languageEnglish (US)
Pages (from-to)13-17
Number of pages5
JournalJournal of Perinatal Medicine
Volume23
Issue number1-2
DOIs
StatePublished - 1995

Fingerprint

Erythropoietin
Health
Serum
Anemia
Hormones
Bone Marrow
Erythropoiesis
Intercellular Signaling Peptides and Proteins
Glycoproteins
Kidney
Food

Keywords

  • Erythropoietin
  • Erythropoietin
  • Erythropoïéetine
  • radio-immunodosage
  • radioimmunoassay
  • Radioimmunoassay

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Serum immunoreactive erythropoietin in health and disease. / Spivak, Jerry L.

In: Journal of Perinatal Medicine, Vol. 23, No. 1-2, 1995, p. 13-17.

Research output: Contribution to journalArticle

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