Serum immunoglobulin G response to human papillomavirus type 16 virus-like particles in human immunodeficiency virus (HIV)-positive and risk-matched HIV-negative women

Raphael P Viscidi, Linda Ahdieh-Grant, Barbara Clayman, Kelly Fox, Leslie S. Massad, Susan Cu-Uvin, Keerti V. Shah, Kathryn M. Anastos, Kathleen E. Squires, Ann Duerr, Denise J. Jamieson, Robert D. Burk, Robert S. Klein, Howard Minkoff, Joel Palefsky, Howard Strickler, Paula Schuman, Eva Piessens, Paolo Miotti

Research output: Contribution to journalArticle

Abstract

Baseline serum samples from 2815 human immunodeficiency virus (HIV)-positive and 963 HIV-negative women enrolled in 2 cohort studies were tested for immunoglobulin G antibodies to human papillomavirus type 16 (HPV-16) capsids. HPV-16 seropositivity was associated with lifetime number of sex partners (P <.001) among both HIV-positive and HIV-negative women. Approximately 50%-60% of HPV-16 DNA-positive women were HPV-16 positive. HPV-16 seropositivity was associated with HIV infection; however, after adjustment for baseline cervical HPV infection and disease, the association disappeared. Thus, the high seroprevalence of HPV-16 among HIV-positive women may be explained by a high prevalence of HPV of all types. Approximately 50% of HIV-positive women had serological evidence of prior HPV-16 infection, but only ∼5% had an HPV-16 cervical infection at baseline. Despite the higher prevalence of HPV infection in this group, most HIV-positive women are able to control HPV-16 replication at the cervix, and reactivation, if it occurs, is not very common.

Original languageEnglish (US)
Pages (from-to)194-205
Number of pages12
JournalJournal of Infectious Diseases
Volume187
Issue number2
DOIs
StatePublished - Jan 15 2003

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Papillomaviridae
Human papillomavirus 16
Virion
Immunoglobulin G
HIV
Serum
Infection
Papillomavirus Infections
Capsid
Seroepidemiologic Studies
Virus Diseases
Cervix Uteri

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Serum immunoglobulin G response to human papillomavirus type 16 virus-like particles in human immunodeficiency virus (HIV)-positive and risk-matched HIV-negative women. / Viscidi, Raphael P; Ahdieh-Grant, Linda; Clayman, Barbara; Fox, Kelly; Massad, Leslie S.; Cu-Uvin, Susan; Shah, Keerti V.; Anastos, Kathryn M.; Squires, Kathleen E.; Duerr, Ann; Jamieson, Denise J.; Burk, Robert D.; Klein, Robert S.; Minkoff, Howard; Palefsky, Joel; Strickler, Howard; Schuman, Paula; Piessens, Eva; Miotti, Paolo.

In: Journal of Infectious Diseases, Vol. 187, No. 2, 15.01.2003, p. 194-205.

Research output: Contribution to journalArticle

Viscidi, RP, Ahdieh-Grant, L, Clayman, B, Fox, K, Massad, LS, Cu-Uvin, S, Shah, KV, Anastos, KM, Squires, KE, Duerr, A, Jamieson, DJ, Burk, RD, Klein, RS, Minkoff, H, Palefsky, J, Strickler, H, Schuman, P, Piessens, E & Miotti, P 2003, 'Serum immunoglobulin G response to human papillomavirus type 16 virus-like particles in human immunodeficiency virus (HIV)-positive and risk-matched HIV-negative women', Journal of Infectious Diseases, vol. 187, no. 2, pp. 194-205. https://doi.org/10.1086/346052
Viscidi, Raphael P ; Ahdieh-Grant, Linda ; Clayman, Barbara ; Fox, Kelly ; Massad, Leslie S. ; Cu-Uvin, Susan ; Shah, Keerti V. ; Anastos, Kathryn M. ; Squires, Kathleen E. ; Duerr, Ann ; Jamieson, Denise J. ; Burk, Robert D. ; Klein, Robert S. ; Minkoff, Howard ; Palefsky, Joel ; Strickler, Howard ; Schuman, Paula ; Piessens, Eva ; Miotti, Paolo. / Serum immunoglobulin G response to human papillomavirus type 16 virus-like particles in human immunodeficiency virus (HIV)-positive and risk-matched HIV-negative women. In: Journal of Infectious Diseases. 2003 ; Vol. 187, No. 2. pp. 194-205.
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