Serum IL-6 levels are associated with significant coronary stenosis in cardiovascularly asymptomatic inner-city black adults in the US

Research output: Contribution to journalArticle

Abstract

Objectives and design: The objective of this study was to explore whether increased levels of inflammatory cytokines are associated with the risk of clinically silent coronary artery disease. Subjects: Three-hundred-fifty-six black adults aged 25-54 residing in inner city of Baltimore, Maryland, United States were included in this study. Methods: Sociodemographics were assessed as were lipid profiles, IL-6, tumor necrosis factor-alpha (TNF-alpha), soluble intercellular adhesion molecule-1 (sICAM-1), and high-sensitivity C-reactive protein (hs-CRP) levels. Computed tomography (CT) coronary angiography was performed. Results: Coronary calcification was identified in 22.5 % participants and 14 % had significant (≥50 %) coronary stenosis. Multiple logistic regression analyses suggested that IL-6 levels were independently associated with the presence of coronary calcification and significant coronary stenosis, while TNF-alpha, sICAM-1 and hs-CRP levels were not. Conclusions: This study underscores a critical role for IL-6 in atherosclerosis and suggests that IL-6 may be a marker for significant coronary stenosis in cardiovascularly asymptomatic individuals.

Original languageEnglish (US)
Pages (from-to)15-21
Number of pages7
JournalInflammation Research
Volume58
Issue number1
DOIs
StatePublished - Jan 2009

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Coronary Stenosis
Interleukin-6
Intercellular Adhesion Molecule-1
Serum
C-Reactive Protein
Tumor Necrosis Factor-alpha
Baltimore
Coronary Angiography
Coronary Artery Disease
Atherosclerosis
Logistic Models
Regression Analysis
Cytokines
Lipids

Keywords

  • Black race
  • CT coronary angiography
  • Interleukin-6 (IL-6)
  • Marker for clinically silent CAD
  • Significant coronary stenosis

ASJC Scopus subject areas

  • Pharmacology
  • Immunology

Cite this

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title = "Serum IL-6 levels are associated with significant coronary stenosis in cardiovascularly asymptomatic inner-city black adults in the US",
abstract = "Objectives and design: The objective of this study was to explore whether increased levels of inflammatory cytokines are associated with the risk of clinically silent coronary artery disease. Subjects: Three-hundred-fifty-six black adults aged 25-54 residing in inner city of Baltimore, Maryland, United States were included in this study. Methods: Sociodemographics were assessed as were lipid profiles, IL-6, tumor necrosis factor-alpha (TNF-alpha), soluble intercellular adhesion molecule-1 (sICAM-1), and high-sensitivity C-reactive protein (hs-CRP) levels. Computed tomography (CT) coronary angiography was performed. Results: Coronary calcification was identified in 22.5 {\%} participants and 14 {\%} had significant (≥50 {\%}) coronary stenosis. Multiple logistic regression analyses suggested that IL-6 levels were independently associated with the presence of coronary calcification and significant coronary stenosis, while TNF-alpha, sICAM-1 and hs-CRP levels were not. Conclusions: This study underscores a critical role for IL-6 in atherosclerosis and suggests that IL-6 may be a marker for significant coronary stenosis in cardiovascularly asymptomatic individuals.",
keywords = "Black race, CT coronary angiography, Interleukin-6 (IL-6), Marker for clinically silent CAD, Significant coronary stenosis",
author = "Shenghan Lai and Fishman, {Elliot K} and Lai, {Hong Chen} and H. Pannu and Barbara Detrick",
year = "2009",
month = "1",
doi = "10.1007/s00011-008-8150-2",
language = "English (US)",
volume = "58",
pages = "15--21",
journal = "Inflammation Research",
issn = "1023-3830",
publisher = "Birkhauser Verlag Basel",
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TY - JOUR

T1 - Serum IL-6 levels are associated with significant coronary stenosis in cardiovascularly asymptomatic inner-city black adults in the US

AU - Lai, Shenghan

AU - Fishman, Elliot K

AU - Lai, Hong Chen

AU - Pannu, H.

AU - Detrick, Barbara

PY - 2009/1

Y1 - 2009/1

N2 - Objectives and design: The objective of this study was to explore whether increased levels of inflammatory cytokines are associated with the risk of clinically silent coronary artery disease. Subjects: Three-hundred-fifty-six black adults aged 25-54 residing in inner city of Baltimore, Maryland, United States were included in this study. Methods: Sociodemographics were assessed as were lipid profiles, IL-6, tumor necrosis factor-alpha (TNF-alpha), soluble intercellular adhesion molecule-1 (sICAM-1), and high-sensitivity C-reactive protein (hs-CRP) levels. Computed tomography (CT) coronary angiography was performed. Results: Coronary calcification was identified in 22.5 % participants and 14 % had significant (≥50 %) coronary stenosis. Multiple logistic regression analyses suggested that IL-6 levels were independently associated with the presence of coronary calcification and significant coronary stenosis, while TNF-alpha, sICAM-1 and hs-CRP levels were not. Conclusions: This study underscores a critical role for IL-6 in atherosclerosis and suggests that IL-6 may be a marker for significant coronary stenosis in cardiovascularly asymptomatic individuals.

AB - Objectives and design: The objective of this study was to explore whether increased levels of inflammatory cytokines are associated with the risk of clinically silent coronary artery disease. Subjects: Three-hundred-fifty-six black adults aged 25-54 residing in inner city of Baltimore, Maryland, United States were included in this study. Methods: Sociodemographics were assessed as were lipid profiles, IL-6, tumor necrosis factor-alpha (TNF-alpha), soluble intercellular adhesion molecule-1 (sICAM-1), and high-sensitivity C-reactive protein (hs-CRP) levels. Computed tomography (CT) coronary angiography was performed. Results: Coronary calcification was identified in 22.5 % participants and 14 % had significant (≥50 %) coronary stenosis. Multiple logistic regression analyses suggested that IL-6 levels were independently associated with the presence of coronary calcification and significant coronary stenosis, while TNF-alpha, sICAM-1 and hs-CRP levels were not. Conclusions: This study underscores a critical role for IL-6 in atherosclerosis and suggests that IL-6 may be a marker for significant coronary stenosis in cardiovascularly asymptomatic individuals.

KW - Black race

KW - CT coronary angiography

KW - Interleukin-6 (IL-6)

KW - Marker for clinically silent CAD

KW - Significant coronary stenosis

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