TY - JOUR
T1 - Serum IL-6 levels are associated with significant coronary stenosis in cardiovascularly asymptomatic inner-city black adults in the US
AU - Lai, S.
AU - Fishman, E. K.
AU - Lai, H.
AU - Pannu, H.
AU - Detrick, B.
N1 - Funding Information:
Acknowledgments. The authors thank those who participated in these studies. The authors wish to thank Nathan Cass, Immunology Laboratory, Department of Pathology, for his expert technical assistance in performing the cytokine assays in this study. This research was funded by National Institute on Drug Abuse grants RO1-DA12777 (Shenghan Lai), and RO1-DA15020 (Shenghan Lai).
Funding Information:
This research was funded by National Institute on Drug Abuse grants RO1-DA12777 (Lai S), and RO1-DA15020 (Lai S).
PY - 2009/1
Y1 - 2009/1
N2 - Objectives and design: The objective of this study was to explore whether increased levels of inflammatory cytokines are associated with the risk of clinically silent coronary artery disease. Subjects: Three-hundred-fifty-six black adults aged 25-54 residing in inner city of Baltimore, Maryland, United States were included in this study. Methods: Sociodemographics were assessed as were lipid profiles, IL-6, tumor necrosis factor-alpha (TNF-alpha), soluble intercellular adhesion molecule-1 (sICAM-1), and high-sensitivity C-reactive protein (hs-CRP) levels. Computed tomography (CT) coronary angiography was performed. Results: Coronary calcification was identified in 22.5 % participants and 14 % had significant (≥50 %) coronary stenosis. Multiple logistic regression analyses suggested that IL-6 levels were independently associated with the presence of coronary calcification and significant coronary stenosis, while TNF-alpha, sICAM-1 and hs-CRP levels were not. Conclusions: This study underscores a critical role for IL-6 in atherosclerosis and suggests that IL-6 may be a marker for significant coronary stenosis in cardiovascularly asymptomatic individuals.
AB - Objectives and design: The objective of this study was to explore whether increased levels of inflammatory cytokines are associated with the risk of clinically silent coronary artery disease. Subjects: Three-hundred-fifty-six black adults aged 25-54 residing in inner city of Baltimore, Maryland, United States were included in this study. Methods: Sociodemographics were assessed as were lipid profiles, IL-6, tumor necrosis factor-alpha (TNF-alpha), soluble intercellular adhesion molecule-1 (sICAM-1), and high-sensitivity C-reactive protein (hs-CRP) levels. Computed tomography (CT) coronary angiography was performed. Results: Coronary calcification was identified in 22.5 % participants and 14 % had significant (≥50 %) coronary stenosis. Multiple logistic regression analyses suggested that IL-6 levels were independently associated with the presence of coronary calcification and significant coronary stenosis, while TNF-alpha, sICAM-1 and hs-CRP levels were not. Conclusions: This study underscores a critical role for IL-6 in atherosclerosis and suggests that IL-6 may be a marker for significant coronary stenosis in cardiovascularly asymptomatic individuals.
KW - Black race
KW - CT coronary angiography
KW - Interleukin-6 (IL-6)
KW - Marker for clinically silent CAD
KW - Significant coronary stenosis
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U2 - 10.1007/s00011-008-8150-2
DO - 10.1007/s00011-008-8150-2
M3 - Article
C2 - 19130178
AN - SCOPUS:58549093236
SN - 1023-3830
VL - 58
SP - 15
EP - 21
JO - Inflammation Research
JF - Inflammation Research
IS - 1
ER -