Serum IgG antibody response to the protective antigen (PA) of Bacillus anthracis induced by anthrax vaccine adsorbed (AVA) among U.S. military personnel

Darrell E. Singer, Rachel Schneerson, Christian T. Bautista, Mark V. Rubertone, John B. Robbins, David N. Taylor

Research output: Contribution to journalArticlepeer-review

Abstract

The seroconversion rates and geometric mean concentrations (GMC) of IgG anti-PA for stored sera from U.S. military personnel immunized 3, 4, and 6 times with the U.S. licensed anthrax vaccine adsorbed were studied. Anti-PA IgG concentrations were measured by ELISA. All 246 vaccinees had low but detectable pre-immunization anti-PA IgG (GMC 1.83 μg/mL). Three doses elicited a GMC of 59.92 μg/mL and a seroconversion rate of 85.3%, four doses elicited a GMC of 157.44 μg/mL and 67.9% and the sixth of 276.95 μg/mL and 45.5%, respectively. The forth dose elicited 100% seroconversion compared to the pre-immunization level. These results should facilitate comparison between different immunization schedules and new vaccines.

Original languageEnglish (US)
Pages (from-to)869-873
Number of pages5
JournalVaccine
Volume26
Issue number7
DOIs
StatePublished - Feb 13 2008
Externally publishedYes

Keywords

  • Anthrax
  • Bacillus anthracis
  • IgG
  • Military
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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