Serum IgE Levels and In Vitro Production of IL-2, IL-4, and IFN-γ in Children with Down's Syndrome

Achille Stabile, Stefano Miceli Sopo, Angela Maria Stabile, Luigi Viola, Gabriella Minchilli, Maria Assunta Pesaresi

Research output: Contribution to journalArticlepeer-review

Abstract

In nine children and one young adult with Down's syndrome (DS), lymphocyte phenotype, total serum IgE levels, and in vitro mononuclear cell (PBMC) proliferative responses to phytohemagglutinin (PHA) plus phorbol myristate acetate (PMA) and human recombinant interleukin-2 (hrIL2), and production of interleukin-2 (IL2), interleukin-4 (IL4), and interferon-gamma (IFNγ) were evaluated. The results showed a normal PBMC proliferative response to mitogens and a normal in vitro production of IL4 and IFNγ, while IL2 production was significantly decreased (p < 0.05). CD8+ cells were significantly increased (p < 0.01) and in five of eight patients with DS the IgE serum levels were lower than those in normal controls. IL4 production was lower in patients with DS with low IgE levels than in those with normal levels of serum IgE.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalPediatric Asthma, Allergy and Immunology
Volume8
Issue number4
DOIs
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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