Serum IgE Levels and In Vitro Production of IL-2, IL-4, and IFN-γ in Children with Down's Syndrome

Achille Stabile; Stefano Miceli Sopo; Angela Maria Stabile; Luigi Viola; Gabriella Minchilli; Maria Assunta Pesaresi

doi:10.1089/pai.1994.8.219

Serum IgE Levels and In Vitro Production of IL-2, IL-4, and IFN-γ in Children with Down's Syndrome

Achille Stabile, Stefano Miceli Sopo, Angela Maria Stabile, Luigi Viola, Gabriella Minchilli, Maria Assunta Pesaresi

Research output: Contribution to journal › Article › peer-review

Abstract

In nine children and one young adult with Down's syndrome (DS), lymphocyte phenotype, total serum IgE levels, and in vitro mononuclear cell (PBMC) proliferative responses to phytohemagglutinin (PHA) plus phorbol myristate acetate (PMA) and human recombinant interleukin-2 (hrIL2), and production of interleukin-2 (IL2), interleukin-4 (IL4), and interferon-gamma (IFNγ) were evaluated. The results showed a normal PBMC proliferative response to mitogens and a normal in vitro production of IL4 and IFNγ, while IL2 production was significantly decreased (p < 0.05). CD8+ cells were significantly increased (p < 0.01) and in five of eight patients with DS the IgE serum levels were lower than those in normal controls. IL4 production was lower in patients with DS with low IgE levels than in those with normal levels of serum IgE.

Original language	English (US)
Pages (from-to)	219-225
Number of pages	7
Journal	Pediatric Asthma, Allergy and Immunology
Volume	8
Issue number	4
DOIs	https://doi.org/10.1089/pai.1994.8.219
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Immunology and Allergy
Pulmonary and Respiratory Medicine

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10.1089/pai.1994.8.219

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title = "Serum IgE Levels and In Vitro Production of IL-2, IL-4, and IFN-γ in Children with Down's Syndrome",

abstract = "In nine children and one young adult with Down's syndrome (DS), lymphocyte phenotype, total serum IgE levels, and in vitro mononuclear cell (PBMC) proliferative responses to phytohemagglutinin (PHA) plus phorbol myristate acetate (PMA) and human recombinant interleukin-2 (hrIL2), and production of interleukin-2 (IL2), interleukin-4 (IL4), and interferon-gamma (IFNγ) were evaluated. The results showed a normal PBMC proliferative response to mitogens and a normal in vitro production of IL4 and IFNγ, while IL2 production was significantly decreased (p < 0.05). CD8+ cells were significantly increased (p < 0.01) and in five of eight patients with DS the IgE serum levels were lower than those in normal controls. IL4 production was lower in patients with DS with low IgE levels than in those with normal levels of serum IgE.",

author = "Achille Stabile and Sopo, {Stefano Miceli} and Stabile, {Angela Maria} and Luigi Viola and Gabriella Minchilli and Pesaresi, {Maria Assunta}",

year = "1994",

doi = "10.1089/pai.1994.8.219",

language = "English (US)",

volume = "8",

pages = "219--225",

journal = "Pediatric Asthma, Allergy and Immunology",

issn = "0883-1874",

publisher = "Mary Ann Liebert Inc.",

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TY - JOUR

T1 - Serum IgE Levels and In Vitro Production of IL-2, IL-4, and IFN-γ in Children with Down's Syndrome

AU - Stabile, Achille

AU - Sopo, Stefano Miceli

AU - Stabile, Angela Maria

AU - Viola, Luigi

AU - Minchilli, Gabriella

AU - Pesaresi, Maria Assunta

PY - 1994

Y1 - 1994

N2 - In nine children and one young adult with Down's syndrome (DS), lymphocyte phenotype, total serum IgE levels, and in vitro mononuclear cell (PBMC) proliferative responses to phytohemagglutinin (PHA) plus phorbol myristate acetate (PMA) and human recombinant interleukin-2 (hrIL2), and production of interleukin-2 (IL2), interleukin-4 (IL4), and interferon-gamma (IFNγ) were evaluated. The results showed a normal PBMC proliferative response to mitogens and a normal in vitro production of IL4 and IFNγ, while IL2 production was significantly decreased (p < 0.05). CD8+ cells were significantly increased (p < 0.01) and in five of eight patients with DS the IgE serum levels were lower than those in normal controls. IL4 production was lower in patients with DS with low IgE levels than in those with normal levels of serum IgE.

AB - In nine children and one young adult with Down's syndrome (DS), lymphocyte phenotype, total serum IgE levels, and in vitro mononuclear cell (PBMC) proliferative responses to phytohemagglutinin (PHA) plus phorbol myristate acetate (PMA) and human recombinant interleukin-2 (hrIL2), and production of interleukin-2 (IL2), interleukin-4 (IL4), and interferon-gamma (IFNγ) were evaluated. The results showed a normal PBMC proliferative response to mitogens and a normal in vitro production of IL4 and IFNγ, while IL2 production was significantly decreased (p < 0.05). CD8+ cells were significantly increased (p < 0.01) and in five of eight patients with DS the IgE serum levels were lower than those in normal controls. IL4 production was lower in patients with DS with low IgE levels than in those with normal levels of serum IgE.

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DO - 10.1089/pai.1994.8.219

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JO - Pediatric Asthma, Allergy and Immunology

JF - Pediatric Asthma, Allergy and Immunology

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ER -

Serum IgE Levels and In Vitro Production of IL-2, IL-4, and IFN-γ in Children with Down's Syndrome

Abstract

ASJC Scopus subject areas

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