Serum growth factors and oncoproteins in firefighters

J. Ford; S. Smith; Jiin Chyuan Luo; G. Friedman-jimenez; P. Brandt-rauf; S. Markowitz; K. Garibaldi; H. Niman

doi:10.1093/occmed/42.1.39

Serum growth factors and oncoproteins in firefighters

J. Ford, S. Smith, Jiin Chyuan Luo, G. Friedman-jimenez, P. Brandt-rauf, S. Markowitz, K. Garibaldi, H. Niman

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Firefighters are potentially at increased risk for cancer and non-malignant respiratory disease due to their toxic exposures on the job. Growth factors and oncogene proteins are thought to play a role in the development of various malignancies and pulmonary fibrotic diseases. Therefore, a cohort of firefighters and matched controls have been screened for the presence of nine different growth factors and oncoproteins using an immunoblotting assay. Fourteen of the firefighters were found to be positive for β-transforming growth factor (β-TGF) related proteins compared to no positives in the controls (P=0.0017). These results suggest that β-TGF may be a possible biomarker for monitoring firefighters and other exposed workers for the potential development of cancer or non-malignant respiratory disease.

Original language	English (US)
Pages (from-to)	39-42
Number of pages	4
Journal	Occupational Medicine
Volume	42
Issue number	1
DOIs	https://doi.org/10.1093/occmed/42.1.39
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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10.1093/occmed/42.1.39

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title = "Serum growth factors and oncoproteins in firefighters",

abstract = "Firefighters are potentially at increased risk for cancer and non-malignant respiratory disease due to their toxic exposures on the job. Growth factors and oncogene proteins are thought to play a role in the development of various malignancies and pulmonary fibrotic diseases. Therefore, a cohort of firefighters and matched controls have been screened for the presence of nine different growth factors and oncoproteins using an immunoblotting assay. Fourteen of the firefighters were found to be positive for β-transforming growth factor (β-TGF) related proteins compared to no positives in the controls (P=0.0017). These results suggest that β-TGF may be a possible biomarker for monitoring firefighters and other exposed workers for the potential development of cancer or non-malignant respiratory disease.",

author = "J. Ford and S. Smith and Luo, {Jiin Chyuan} and G. Friedman-jimenez and P. Brandt-rauf and S. Markowitz and K. Garibaldi and H. Niman",

note = "Funding Information: This work was supported in part by grant number OH00076 from the National Institute for Occupational Safety and Health of the Centers for Disease Control, a grant from the New York State Professional Firefighters, Inc., and U.S. Public Health Service training grants T32-HL07018 and T32-CA09529. The authors would also like to thank Dr Peter Caldwell for his support and encouragement of this research.",

year = "1992",

doi = "10.1093/occmed/42.1.39",

language = "English (US)",

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T1 - Serum growth factors and oncoproteins in firefighters

AU - Ford, J.

AU - Smith, S.

AU - Luo, Jiin Chyuan

AU - Friedman-jimenez, G.

AU - Brandt-rauf, P.

AU - Markowitz, S.

AU - Garibaldi, K.

AU - Niman, H.

N1 - Funding Information: This work was supported in part by grant number OH00076 from the National Institute for Occupational Safety and Health of the Centers for Disease Control, a grant from the New York State Professional Firefighters, Inc., and U.S. Public Health Service training grants T32-HL07018 and T32-CA09529. The authors would also like to thank Dr Peter Caldwell for his support and encouragement of this research.

PY - 1992

Y1 - 1992

N2 - Firefighters are potentially at increased risk for cancer and non-malignant respiratory disease due to their toxic exposures on the job. Growth factors and oncogene proteins are thought to play a role in the development of various malignancies and pulmonary fibrotic diseases. Therefore, a cohort of firefighters and matched controls have been screened for the presence of nine different growth factors and oncoproteins using an immunoblotting assay. Fourteen of the firefighters were found to be positive for β-transforming growth factor (β-TGF) related proteins compared to no positives in the controls (P=0.0017). These results suggest that β-TGF may be a possible biomarker for monitoring firefighters and other exposed workers for the potential development of cancer or non-malignant respiratory disease.

AB - Firefighters are potentially at increased risk for cancer and non-malignant respiratory disease due to their toxic exposures on the job. Growth factors and oncogene proteins are thought to play a role in the development of various malignancies and pulmonary fibrotic diseases. Therefore, a cohort of firefighters and matched controls have been screened for the presence of nine different growth factors and oncoproteins using an immunoblotting assay. Fourteen of the firefighters were found to be positive for β-transforming growth factor (β-TGF) related proteins compared to no positives in the controls (P=0.0017). These results suggest that β-TGF may be a possible biomarker for monitoring firefighters and other exposed workers for the potential development of cancer or non-malignant respiratory disease.

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Serum growth factors and oncoproteins in firefighters

Abstract

ASJC Scopus subject areas

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