Serum globulin in myasthenia gravis: Inhibition of α-bungarotoxin binding to acetylcholine receptors

Richard R. Almon, Clifford Andrew, Stanley H. Appel

Research output: Contribution to journalArticle

Abstract

Serum factors that inhibit the binding of 125I-labeled α-bungarotoxin to the acetylcholine receptor extracted in detergent from denervated rat muscle were detected by a sensitive assay. The serum of at least 5 and possibly 11 out of 15 patients with myasthenia gravis showed inhibitory activity that was localized to the globulin fraction. No controls showed inhibitory activity. The demonstration of inhibitory globulins may help explain the involvement of the immune system in the pathophysiology of the neuromuscular junction in patients with myasthenia gravis.

Original languageEnglish (US)
Pages (from-to)55-57
Number of pages3
JournalScience
Volume186
Issue number4158
Publication statusPublished - 1974
Externally publishedYes

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