Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children

Andrew Nicholson, Suzanne Pollard, John J. Lima, Karina M. Romero, Carla Tarazona-Meza, Gary Malpartida-Guzmán, Edward Mougey, Nadia Hansel, William Checkley

Research output: Contribution to journalArticle

Abstract

Background The relationship between folate status and asthma-related outcomes has not been carefully examined in low- and middle-income countries where folate deficiency is common. Methods Ancillary analysis of an unmatched case-control study in which we analyzed serum folate concentrations in 412 children with asthma and 342 controls living in peri-urban communities in Lima, Peru. We examined baseline associations between folate and asthma, atopy, total serum IgE, pulmonary function, and fractional exhaled nitric oxide. We then followed children with asthma longitudinally for 6–9 months and assessed associations between folate and odds of uncontrolled asthma (defined as Asthma Control Test score ≤ 19) and of ≥1 emergency visits during follow-up. Results A 10 ng/mL decrease in serum folate was associated with 45% higher adjusted odds of asthma (OR = 1.45, 95% CI 1.05–2.02). The folate-asthma relationship differed by atopic status: a 10 ng/mL decrease in serum folate was associated with a 2.4-fold higher odds of asthma among children without atopy (2.38, 1.20–4.72) and 23% higher odds of asthma in children with atopy (1.23, 0.85–1.80). Among children with asthma, a 10 ng/mL decrease in serum folate was associated with 62% higher odds of uncontrolled asthma (1.62, 1.02–2.56) and 73% higher odds of ≥1 emergency visits during follow-up (1.73, 1.05–2.85). Conclusions Serum folate concentrations were inversely associated with asthma, but this effect was stronger in children without atopy. Among children with asthma, lower serum folate concentrations were associated with higher risk of uncontrolled asthma.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalRespiratory Medicine
Volume133
DOIs
StatePublished - Dec 1 2017

Fingerprint

Folic Acid
Asthma
Serum
Emergencies
Peru
antineoplaston A10
Immunoglobulin E
Case-Control Studies
Nitric Oxide

Keywords

  • Asthma
  • Asthma control
  • Atopy
  • Folate
  • Pediatric asthma
  • Peruvians

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children. / Nicholson, Andrew; Pollard, Suzanne; Lima, John J.; Romero, Karina M.; Tarazona-Meza, Carla; Malpartida-Guzmán, Gary; Mougey, Edward; Hansel, Nadia; Checkley, William.

In: Respiratory Medicine, Vol. 133, 01.12.2017, p. 29-35.

Research output: Contribution to journalArticle

Nicholson A, Pollard S, Lima JJ, Romero KM, Tarazona-Meza C, Malpartida-Guzmán G et al. Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children. Respiratory Medicine. 2017 Dec 1;133:29-35. https://doi.org/10.1016/j.rmed.2017.10.026
Nicholson, Andrew ; Pollard, Suzanne ; Lima, John J. ; Romero, Karina M. ; Tarazona-Meza, Carla ; Malpartida-Guzmán, Gary ; Mougey, Edward ; Hansel, Nadia ; Checkley, William. / Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children. In: Respiratory Medicine. 2017 ; Vol. 133. pp. 29-35.
@article{4da6c420313e45d7b563305667eb1249,
title = "Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children",
abstract = "Background The relationship between folate status and asthma-related outcomes has not been carefully examined in low- and middle-income countries where folate deficiency is common. Methods Ancillary analysis of an unmatched case-control study in which we analyzed serum folate concentrations in 412 children with asthma and 342 controls living in peri-urban communities in Lima, Peru. We examined baseline associations between folate and asthma, atopy, total serum IgE, pulmonary function, and fractional exhaled nitric oxide. We then followed children with asthma longitudinally for 6–9 months and assessed associations between folate and odds of uncontrolled asthma (defined as Asthma Control Test score ≤ 19) and of ≥1 emergency visits during follow-up. Results A 10 ng/mL decrease in serum folate was associated with 45{\%} higher adjusted odds of asthma (OR = 1.45, 95{\%} CI 1.05–2.02). The folate-asthma relationship differed by atopic status: a 10 ng/mL decrease in serum folate was associated with a 2.4-fold higher odds of asthma among children without atopy (2.38, 1.20–4.72) and 23{\%} higher odds of asthma in children with atopy (1.23, 0.85–1.80). Among children with asthma, a 10 ng/mL decrease in serum folate was associated with 62{\%} higher odds of uncontrolled asthma (1.62, 1.02–2.56) and 73{\%} higher odds of ≥1 emergency visits during follow-up (1.73, 1.05–2.85). Conclusions Serum folate concentrations were inversely associated with asthma, but this effect was stronger in children without atopy. Among children with asthma, lower serum folate concentrations were associated with higher risk of uncontrolled asthma.",
keywords = "Asthma, Asthma control, Atopy, Folate, Pediatric asthma, Peruvians",
author = "Andrew Nicholson and Suzanne Pollard and Lima, {John J.} and Romero, {Karina M.} and Carla Tarazona-Meza and Gary Malpartida-Guzm{\'a}n and Edward Mougey and Nadia Hansel and William Checkley",
year = "2017",
month = "12",
day = "1",
doi = "10.1016/j.rmed.2017.10.026",
language = "English (US)",
volume = "133",
pages = "29--35",
journal = "Respiratory Medicine",
issn = "0954-6111",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children

AU - Nicholson, Andrew

AU - Pollard, Suzanne

AU - Lima, John J.

AU - Romero, Karina M.

AU - Tarazona-Meza, Carla

AU - Malpartida-Guzmán, Gary

AU - Mougey, Edward

AU - Hansel, Nadia

AU - Checkley, William

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background The relationship between folate status and asthma-related outcomes has not been carefully examined in low- and middle-income countries where folate deficiency is common. Methods Ancillary analysis of an unmatched case-control study in which we analyzed serum folate concentrations in 412 children with asthma and 342 controls living in peri-urban communities in Lima, Peru. We examined baseline associations between folate and asthma, atopy, total serum IgE, pulmonary function, and fractional exhaled nitric oxide. We then followed children with asthma longitudinally for 6–9 months and assessed associations between folate and odds of uncontrolled asthma (defined as Asthma Control Test score ≤ 19) and of ≥1 emergency visits during follow-up. Results A 10 ng/mL decrease in serum folate was associated with 45% higher adjusted odds of asthma (OR = 1.45, 95% CI 1.05–2.02). The folate-asthma relationship differed by atopic status: a 10 ng/mL decrease in serum folate was associated with a 2.4-fold higher odds of asthma among children without atopy (2.38, 1.20–4.72) and 23% higher odds of asthma in children with atopy (1.23, 0.85–1.80). Among children with asthma, a 10 ng/mL decrease in serum folate was associated with 62% higher odds of uncontrolled asthma (1.62, 1.02–2.56) and 73% higher odds of ≥1 emergency visits during follow-up (1.73, 1.05–2.85). Conclusions Serum folate concentrations were inversely associated with asthma, but this effect was stronger in children without atopy. Among children with asthma, lower serum folate concentrations were associated with higher risk of uncontrolled asthma.

AB - Background The relationship between folate status and asthma-related outcomes has not been carefully examined in low- and middle-income countries where folate deficiency is common. Methods Ancillary analysis of an unmatched case-control study in which we analyzed serum folate concentrations in 412 children with asthma and 342 controls living in peri-urban communities in Lima, Peru. We examined baseline associations between folate and asthma, atopy, total serum IgE, pulmonary function, and fractional exhaled nitric oxide. We then followed children with asthma longitudinally for 6–9 months and assessed associations between folate and odds of uncontrolled asthma (defined as Asthma Control Test score ≤ 19) and of ≥1 emergency visits during follow-up. Results A 10 ng/mL decrease in serum folate was associated with 45% higher adjusted odds of asthma (OR = 1.45, 95% CI 1.05–2.02). The folate-asthma relationship differed by atopic status: a 10 ng/mL decrease in serum folate was associated with a 2.4-fold higher odds of asthma among children without atopy (2.38, 1.20–4.72) and 23% higher odds of asthma in children with atopy (1.23, 0.85–1.80). Among children with asthma, a 10 ng/mL decrease in serum folate was associated with 62% higher odds of uncontrolled asthma (1.62, 1.02–2.56) and 73% higher odds of ≥1 emergency visits during follow-up (1.73, 1.05–2.85). Conclusions Serum folate concentrations were inversely associated with asthma, but this effect was stronger in children without atopy. Among children with asthma, lower serum folate concentrations were associated with higher risk of uncontrolled asthma.

KW - Asthma

KW - Asthma control

KW - Atopy

KW - Folate

KW - Pediatric asthma

KW - Peruvians

UR - http://www.scopus.com/inward/record.url?scp=85034063679&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034063679&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2017.10.026

DO - 10.1016/j.rmed.2017.10.026

M3 - Article

C2 - 29173446

AN - SCOPUS:85034063679

VL - 133

SP - 29

EP - 35

JO - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

ER -