Abstract
Background The relationship between folate status and asthma-related outcomes has not been carefully examined in low- and middle-income countries where folate deficiency is common. Methods Ancillary analysis of an unmatched case-control study in which we analyzed serum folate concentrations in 412 children with asthma and 342 controls living in peri-urban communities in Lima, Peru. We examined baseline associations between folate and asthma, atopy, total serum IgE, pulmonary function, and fractional exhaled nitric oxide. We then followed children with asthma longitudinally for 6–9 months and assessed associations between folate and odds of uncontrolled asthma (defined as Asthma Control Test score ≤ 19) and of ≥1 emergency visits during follow-up. Results A 10 ng/mL decrease in serum folate was associated with 45% higher adjusted odds of asthma (OR = 1.45, 95% CI 1.05–2.02). The folate-asthma relationship differed by atopic status: a 10 ng/mL decrease in serum folate was associated with a 2.4-fold higher odds of asthma among children without atopy (2.38, 1.20–4.72) and 23% higher odds of asthma in children with atopy (1.23, 0.85–1.80). Among children with asthma, a 10 ng/mL decrease in serum folate was associated with 62% higher odds of uncontrolled asthma (1.62, 1.02–2.56) and 73% higher odds of ≥1 emergency visits during follow-up (1.73, 1.05–2.85). Conclusions Serum folate concentrations were inversely associated with asthma, but this effect was stronger in children without atopy. Among children with asthma, lower serum folate concentrations were associated with higher risk of uncontrolled asthma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 29-35 |
| Number of pages | 7 |
| Journal | Respiratory Medicine |
| Volume | 133 |
| DOIs | |
| State | Published - Dec 1 2017 |
Fingerprint
Keywords
- Asthma
- Asthma control
- Atopy
- Folate
- Pediatric asthma
- Peruvians
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children. / Nicholson, Andrew; Pollard, Suzanne; Lima, John J.; Romero, Karina M.; Tarazona-Meza, Carla; Malpartida-Guzmán, Gary; Mougey, Edward; Hansel, Nadia; Checkley, William.
In: Respiratory Medicine, Vol. 133, 01.12.2017, p. 29-35.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum folate concentrations, asthma, atopy, and asthma control in Peruvian children
AU - Nicholson, Andrew
AU - Pollard, Suzanne
AU - Lima, John J.
AU - Romero, Karina M.
AU - Tarazona-Meza, Carla
AU - Malpartida-Guzmán, Gary
AU - Mougey, Edward
AU - Hansel, Nadia
AU - Checkley, William
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Background The relationship between folate status and asthma-related outcomes has not been carefully examined in low- and middle-income countries where folate deficiency is common. Methods Ancillary analysis of an unmatched case-control study in which we analyzed serum folate concentrations in 412 children with asthma and 342 controls living in peri-urban communities in Lima, Peru. We examined baseline associations between folate and asthma, atopy, total serum IgE, pulmonary function, and fractional exhaled nitric oxide. We then followed children with asthma longitudinally for 6–9 months and assessed associations between folate and odds of uncontrolled asthma (defined as Asthma Control Test score ≤ 19) and of ≥1 emergency visits during follow-up. Results A 10 ng/mL decrease in serum folate was associated with 45% higher adjusted odds of asthma (OR = 1.45, 95% CI 1.05–2.02). The folate-asthma relationship differed by atopic status: a 10 ng/mL decrease in serum folate was associated with a 2.4-fold higher odds of asthma among children without atopy (2.38, 1.20–4.72) and 23% higher odds of asthma in children with atopy (1.23, 0.85–1.80). Among children with asthma, a 10 ng/mL decrease in serum folate was associated with 62% higher odds of uncontrolled asthma (1.62, 1.02–2.56) and 73% higher odds of ≥1 emergency visits during follow-up (1.73, 1.05–2.85). Conclusions Serum folate concentrations were inversely associated with asthma, but this effect was stronger in children without atopy. Among children with asthma, lower serum folate concentrations were associated with higher risk of uncontrolled asthma.
AB - Background The relationship between folate status and asthma-related outcomes has not been carefully examined in low- and middle-income countries where folate deficiency is common. Methods Ancillary analysis of an unmatched case-control study in which we analyzed serum folate concentrations in 412 children with asthma and 342 controls living in peri-urban communities in Lima, Peru. We examined baseline associations between folate and asthma, atopy, total serum IgE, pulmonary function, and fractional exhaled nitric oxide. We then followed children with asthma longitudinally for 6–9 months and assessed associations between folate and odds of uncontrolled asthma (defined as Asthma Control Test score ≤ 19) and of ≥1 emergency visits during follow-up. Results A 10 ng/mL decrease in serum folate was associated with 45% higher adjusted odds of asthma (OR = 1.45, 95% CI 1.05–2.02). The folate-asthma relationship differed by atopic status: a 10 ng/mL decrease in serum folate was associated with a 2.4-fold higher odds of asthma among children without atopy (2.38, 1.20–4.72) and 23% higher odds of asthma in children with atopy (1.23, 0.85–1.80). Among children with asthma, a 10 ng/mL decrease in serum folate was associated with 62% higher odds of uncontrolled asthma (1.62, 1.02–2.56) and 73% higher odds of ≥1 emergency visits during follow-up (1.73, 1.05–2.85). Conclusions Serum folate concentrations were inversely associated with asthma, but this effect was stronger in children without atopy. Among children with asthma, lower serum folate concentrations were associated with higher risk of uncontrolled asthma.
KW - Asthma
KW - Asthma control
KW - Atopy
KW - Folate
KW - Pediatric asthma
KW - Peruvians
UR - http://www.scopus.com/inward/record.url?scp=85034063679&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034063679&partnerID=8YFLogxK
U2 - 10.1016/j.rmed.2017.10.026
DO - 10.1016/j.rmed.2017.10.026
M3 - Article
C2 - 29173446
AN - SCOPUS:85034063679
VL - 133
SP - 29
EP - 35
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
ER -