Serum folate and ddt isomers and metabolites are inversely associated in chinese women: A cross-sectional analysis

Lester M. Arguelles, Xue Liu, Scott A. Venners, Alayne G. Ronnenberg, Zhiping Li, Fan Yang, Jianhua Yang, Xiping Xu, Xiaobin Wang

Research output: Contribution to journalArticle

Abstract

Background: Vitamin nutritional status may influence some xenobiotic metabolism or vice versa. Methods: This analysis examines the relationship between B-vitamin concentrations and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDT) isomers and metabolites in healthy women. Serum pp′DDT, pp′DDE, pp′DDD, op′DDT, op′DDE, and serum folate, cysteine, and vitamins B6 and B12 were measured in 296 nonsmoking female textile workers (21–34 yr) in Anhui, China. Mean (SD) age and body mass index of this cohort were 24.9 (1.5) y and 19.7 (2.0) kg/m2, respectively. Results: Median pp′DDT, pp′DDE, pp′DDD, op′DDT, and op′DDE were 1.5, 29.2, 0.22, 0.17, and 0.09 ng/g, respectively. Median folate and cysteine were 9.2 and 200.0 nmol/L, respectively. Folate was significantly inversely associated with pp′DDT and pp′DDE: β (95% confidence interval [CI])  =  −0.23 (−0.39, −0.07) and −0.20 (−0.36, −0.05), respectively, and it was marginally associated with pp′DDD. Cysteine was significantly inversely associated with pp′DDT, β (95% CI)  =  −0.69 (−1.00, −0.37); pp′DDE, β (95% CI)  =  −0.32 (−0.62, −0.02); pp′DDD, β (95% CI)  =  −0.31 (−0.59, −0.03); and op′DDT, β (95% CI)  =  −0.35 (−0.68, −0.02). Conclusions: Folate and cysteine are independently inversely associated with DDT isomers, adjusting for vitamins B6 and B12, age, and body mass index. These nutrients may play a role in DDT metabolism; however, it is also possible that DDT may exert a negative impact on folate and cysteine levels. Longitudinal studies are needed to ascertain the direction of this association.

Original languageEnglish (US)
Pages (from-to)380-387
Number of pages8
JournalJournal of the American College of Nutrition
Volume28
Issue number4
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

Keywords

  • Cysteine
  • Ddt isomers/metabolites
  • Folate
  • Vitamin b12
  • Vitamin b6

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Serum folate and ddt isomers and metabolites are inversely associated in chinese women: A cross-sectional analysis'. Together they form a unique fingerprint.

  • Cite this