Abstract
In multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), relapses are markedly reduced during pregnancy. Exosomes are lipid-bound vesicles and are more abundant in the serum during pregnancy. Using murine EAE, we demonstrate that serum exosomes suppress T cell activation, promote the maturation of oligodendrocyte precursor cells (OPC), and pregnancy exosomes facilitate OPC migration into active CNS lesions. However, exosomes derived from both pregnant and non-pregnant mice reduced the severity of established EAE. Thus, during pregnancy, serum exosomes modulate the immune and central nervous systems and contribute to pregnancy-associated suppression of EAE.
Original language | English (US) |
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Pages (from-to) | 236-243 |
Number of pages | 8 |
Journal | Clinical Immunology |
Volume | 149 |
Issue number | 2 |
DOIs | |
State | Published - Nov 2013 |
Externally published | Yes |
Keywords
- Exosome
- Experimental autoimmune encephalomyelitis
- Multiple sclerosis
- Oligodendrocyte precursor cell
- Pregnancy
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology