Serum exosomes in pregnancy-associated immune modulation and neuroprotection during CNS autoimmunity

Jessica L. Williams, Na Tosha N. Gatson, Kristen M. Smith, Akshata Almad, Dana M. McTigue, Caroline C. Whitacre

Research output: Contribution to journalArticlepeer-review

Abstract

In multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), relapses are markedly reduced during pregnancy. Exosomes are lipid-bound vesicles and are more abundant in the serum during pregnancy. Using murine EAE, we demonstrate that serum exosomes suppress T cell activation, promote the maturation of oligodendrocyte precursor cells (OPC), and pregnancy exosomes facilitate OPC migration into active CNS lesions. However, exosomes derived from both pregnant and non-pregnant mice reduced the severity of established EAE. Thus, during pregnancy, serum exosomes modulate the immune and central nervous systems and contribute to pregnancy-associated suppression of EAE.

Original languageEnglish (US)
Pages (from-to)236-243
Number of pages8
JournalClinical Immunology
Volume149
Issue number2
DOIs
StatePublished - Nov 2013

Keywords

  • Exosome
  • Experimental autoimmune encephalomyelitis
  • Multiple sclerosis
  • Oligodendrocyte precursor cell
  • Pregnancy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Serum exosomes in pregnancy-associated immune modulation and neuroprotection during CNS autoimmunity'. Together they form a unique fingerprint.

Cite this