Serum copper and zinc measurements in patients with osteogenic sarcoma

D. N. Breiter, R. B. Diasio, J. P. Neifeld, M. L. Roush, S. A. Rosenberg

Research output: Contribution to journalArticle

Abstract

Serum copper level (SCL), serum zinc level (SZL), and SCL/SZL ratio were measured in 18 patients with biopsy-proven osteogenic sarcoma. Measurements were made on sequentially collected serum samples beginning prior to the institution of therapy and continuing periodically until documented relapse. All patients were treated by curative resection and adjuvant therapy consisting of high dose methotrexate (with leucovorin rescue) with or without BCG immunotherapy. The SCL, SZL, and SCL/SZL determinations were made using proton-induced x-ray fluorescence spectrometry. SCL was significantly elevated (p

Original languageEnglish (US)
Pages (from-to)598-602
Number of pages5
JournalCancer
Volume42
Issue number2
StatePublished - 1978
Externally publishedYes

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Osteosarcoma
Zinc
Copper
Serum
Leucovorin
Fluorescence Spectrometry
Mycobacterium bovis
Methotrexate
Immunotherapy
Protons
X-Rays
Biopsy
Recurrence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Breiter, D. N., Diasio, R. B., Neifeld, J. P., Roush, M. L., & Rosenberg, S. A. (1978). Serum copper and zinc measurements in patients with osteogenic sarcoma. Cancer, 42(2), 598-602.

Serum copper and zinc measurements in patients with osteogenic sarcoma. / Breiter, D. N.; Diasio, R. B.; Neifeld, J. P.; Roush, M. L.; Rosenberg, S. A.

In: Cancer, Vol. 42, No. 2, 1978, p. 598-602.

Research output: Contribution to journalArticle

Breiter, DN, Diasio, RB, Neifeld, JP, Roush, ML & Rosenberg, SA 1978, 'Serum copper and zinc measurements in patients with osteogenic sarcoma', Cancer, vol. 42, no. 2, pp. 598-602.
Breiter DN, Diasio RB, Neifeld JP, Roush ML, Rosenberg SA. Serum copper and zinc measurements in patients with osteogenic sarcoma. Cancer. 1978;42(2):598-602.
Breiter, D. N. ; Diasio, R. B. ; Neifeld, J. P. ; Roush, M. L. ; Rosenberg, S. A. / Serum copper and zinc measurements in patients with osteogenic sarcoma. In: Cancer. 1978 ; Vol. 42, No. 2. pp. 598-602.
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