Serum concentrations of retinol, α-tocopherol and the carotenoids are influenced by diet, race and obesity in a sample of healthy adolescents

M. L. Neuhouser, C. L. Rock, A. L. Eldridge, A. R. Kristal, R. E. Patterson, D. A. Cooper, D. Neumark-Sztainer, Lawrence J Cheskin, M. D. Thornquist

Research output: Contribution to journalArticle

Abstract

An important part of understanding the functions of vitamin A, vitamin E and the carotenoids in nutritional status assessment, health promotion and disease prevention is knowledge of factors that influence their distribution in human tissues. Our objective was to examine serum concentrations of these nutrients and compounds in a sample of 285 healthy participants, 12-17 y old, from three U. S. cities. Pearson correlations between diet measured with a food frequency questionnaire and serum nutrient concentrations among these adolescents (adjusted for total serum cholesterol, age, sex, race and body mass index) were as follows: retinol, 0.23; α-tocopherol, 0.16; a-carotene, 0.31; β-carotene, 0.15; β-cryptoxanthin, 0.38; lycopene, 0.08; and lutein + zeaxanthin, 0.25. Multivariate linear regression modeled associations of demographic, dietary and physiologic variables with serum concentrations of these nutrients. African-American participants had significantly lower concentrations of serum retinol (P <0.001), α-tocopherol (P <0.01) and α-carotene (P <0.02), but higher concentrations of lutein + zeaxanthin (P = 0.001) compared with Caucasians. Obese participants had serum nutrient concentrations that were 2-10% (P <0.05) lower than normal weight participants. Dietary intake was a significant predictor of all serum analytes (P <0.01) except lycopene. These models explained 20% of the variability in serum retinol, 28% of the variability in serum a-tocopherol, and 14-24% of the variability in serum carotenoids.

Original languageEnglish (US)
Pages (from-to)2184-2191
Number of pages8
JournalJournal of Nutrition
Volume131
Issue number8
StatePublished - 2001
Externally publishedYes

Fingerprint

Tocopherols
Carotenoids
Vitamin A
tocopherols
vitamin A
carotenoids
obesity
nutrient content
carotenes
Obesity
Diet
zeaxanthin
lycopene
Serum
lutein
diet
sampling
Food
health promotion
disease prevention

Keywords

  • α-tocopherol
  • Adolescents
  • Carotenoids
  • Dietary assessment
  • Humans
  • Retinol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Neuhouser, M. L., Rock, C. L., Eldridge, A. L., Kristal, A. R., Patterson, R. E., Cooper, D. A., ... Thornquist, M. D. (2001). Serum concentrations of retinol, α-tocopherol and the carotenoids are influenced by diet, race and obesity in a sample of healthy adolescents. Journal of Nutrition, 131(8), 2184-2191.

Serum concentrations of retinol, α-tocopherol and the carotenoids are influenced by diet, race and obesity in a sample of healthy adolescents. / Neuhouser, M. L.; Rock, C. L.; Eldridge, A. L.; Kristal, A. R.; Patterson, R. E.; Cooper, D. A.; Neumark-Sztainer, D.; Cheskin, Lawrence J; Thornquist, M. D.

In: Journal of Nutrition, Vol. 131, No. 8, 2001, p. 2184-2191.

Research output: Contribution to journalArticle

Neuhouser, ML, Rock, CL, Eldridge, AL, Kristal, AR, Patterson, RE, Cooper, DA, Neumark-Sztainer, D, Cheskin, LJ & Thornquist, MD 2001, 'Serum concentrations of retinol, α-tocopherol and the carotenoids are influenced by diet, race and obesity in a sample of healthy adolescents', Journal of Nutrition, vol. 131, no. 8, pp. 2184-2191.
Neuhouser, M. L. ; Rock, C. L. ; Eldridge, A. L. ; Kristal, A. R. ; Patterson, R. E. ; Cooper, D. A. ; Neumark-Sztainer, D. ; Cheskin, Lawrence J ; Thornquist, M. D. / Serum concentrations of retinol, α-tocopherol and the carotenoids are influenced by diet, race and obesity in a sample of healthy adolescents. In: Journal of Nutrition. 2001 ; Vol. 131, No. 8. pp. 2184-2191.
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abstract = "An important part of understanding the functions of vitamin A, vitamin E and the carotenoids in nutritional status assessment, health promotion and disease prevention is knowledge of factors that influence their distribution in human tissues. Our objective was to examine serum concentrations of these nutrients and compounds in a sample of 285 healthy participants, 12-17 y old, from three U. S. cities. Pearson correlations between diet measured with a food frequency questionnaire and serum nutrient concentrations among these adolescents (adjusted for total serum cholesterol, age, sex, race and body mass index) were as follows: retinol, 0.23; α-tocopherol, 0.16; a-carotene, 0.31; β-carotene, 0.15; β-cryptoxanthin, 0.38; lycopene, 0.08; and lutein + zeaxanthin, 0.25. Multivariate linear regression modeled associations of demographic, dietary and physiologic variables with serum concentrations of these nutrients. African-American participants had significantly lower concentrations of serum retinol (P <0.001), α-tocopherol (P <0.01) and α-carotene (P <0.02), but higher concentrations of lutein + zeaxanthin (P = 0.001) compared with Caucasians. Obese participants had serum nutrient concentrations that were 2-10{\%} (P <0.05) lower than normal weight participants. Dietary intake was a significant predictor of all serum analytes (P <0.01) except lycopene. These models explained 20{\%} of the variability in serum retinol, 28{\%} of the variability in serum a-tocopherol, and 14-24{\%} of the variability in serum carotenoids.",
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AU - Kristal, A. R.

AU - Patterson, R. E.

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