Serum antibodies to HIV-1 are produced post-measles virus infection: Evidence for cross-reactivity with HLA

P. V. Baskar; G. D. Collins; B. A. Dorsey-Cooper; R. S. Pyle; J. E. Nagel; D. Dwyer; G. Dunston; C. E. Johnson; N. Kendig; E. Israel; D. R. Nalin; W. H. Adler

doi:10.1046/j.1365-2249.1998.00488.x

Serum antibodies to HIV-1 are produced post-measles virus infection: Evidence for cross-reactivity with HLA

P. V. Baskar, G. D. Collins, B. A. Dorsey-Cooper, R. S. Pyle, J. E. Nagel, D. Dwyer, G. Dunston, C. E. Johnson, N. Kendig, E. Israel, D. R. Nalin, W. H. Adler

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Convalescent sera obtained from patients who were recently recovered from an acute measles virus infection were tested for the presence of anti- HIV-1 antibodies by Western blot analysis. While 16% (17/104) of control sera displayed reactive bands to a variety of HIV proteins, 62% (45/73) of convalescent sera demonstrated immunoreactive bands corresponding to HIV-1 Pol and Gag, but not Env antigens. This cross-reactivity appears to be the result of an active measles infection. No HIV-1 immunoblot reactivity (0/10) was observed in sera obtained from young adults several weeks after a combined measles, mumps, and rubella (MMR) vaccination. Interestingly, examination of anti-HLA typing sera specific for either class I and class II molecules revealed that 46% (19/41) of these sera contained cross-reactive antibodies to HIV-1 proteins. Absorption of measles sera with mixed lymphocyte reaction (MLR)-activated lymphocytes and/or HIV-1 recombinant proteins significantly decreased or removed the presence of these HIV-1- immunoreactive antibodies. Together, these findings suggest that the immune response to a natural measles virus infection results in the production of antibodies to HIV-1 and possibly autoantigens.

Original language	English (US)
Pages (from-to)	251-256
Number of pages	6
Journal	Clinical and Experimental Immunology
Volume	111
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2249.1998.00488.x
State	Published - 1998
Externally published	Yes

Keywords

HIV-1
Indeterminate Western blot
Measles

ASJC Scopus subject areas

General Medicine

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10.1046/j.1365-2249.1998.00488.x

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Baskar, P. V., Collins, G. D., Dorsey-Cooper, B. A., Pyle, R. S., Nagel, J. E., Dwyer, D., Dunston, G., Johnson, C. E., Kendig, N., Israel, E., Nalin, D. R., & Adler, W. H. (1998). Serum antibodies to HIV-1 are produced post-measles virus infection: Evidence for cross-reactivity with HLA. Clinical and Experimental Immunology, 111(2), 251-256. https://doi.org/10.1046/j.1365-2249.1998.00488.x

Baskar, PV, Collins, GD, Dorsey-Cooper, BA, Pyle, RS, Nagel, JE, Dwyer, D, Dunston, G, Johnson, CE, Kendig, N, Israel, E, Nalin, DR & Adler, WH 1998, 'Serum antibodies to HIV-1 are produced post-measles virus infection: Evidence for cross-reactivity with HLA', Clinical and Experimental Immunology, vol. 111, no. 2, pp. 251-256. https://doi.org/10.1046/j.1365-2249.1998.00488.x

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abstract = "Convalescent sera obtained from patients who were recently recovered from an acute measles virus infection were tested for the presence of anti- HIV-1 antibodies by Western blot analysis. While 16% (17/104) of control sera displayed reactive bands to a variety of HIV proteins, 62% (45/73) of convalescent sera demonstrated immunoreactive bands corresponding to HIV-1 Pol and Gag, but not Env antigens. This cross-reactivity appears to be the result of an active measles infection. No HIV-1 immunoblot reactivity (0/10) was observed in sera obtained from young adults several weeks after a combined measles, mumps, and rubella (MMR) vaccination. Interestingly, examination of anti-HLA typing sera specific for either class I and class II molecules revealed that 46% (19/41) of these sera contained cross-reactive antibodies to HIV-1 proteins. Absorption of measles sera with mixed lymphocyte reaction (MLR)-activated lymphocytes and/or HIV-1 recombinant proteins significantly decreased or removed the presence of these HIV-1- immunoreactive antibodies. Together, these findings suggest that the immune response to a natural measles virus infection results in the production of antibodies to HIV-1 and possibly autoantigens.",

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AB - Convalescent sera obtained from patients who were recently recovered from an acute measles virus infection were tested for the presence of anti- HIV-1 antibodies by Western blot analysis. While 16% (17/104) of control sera displayed reactive bands to a variety of HIV proteins, 62% (45/73) of convalescent sera demonstrated immunoreactive bands corresponding to HIV-1 Pol and Gag, but not Env antigens. This cross-reactivity appears to be the result of an active measles infection. No HIV-1 immunoblot reactivity (0/10) was observed in sera obtained from young adults several weeks after a combined measles, mumps, and rubella (MMR) vaccination. Interestingly, examination of anti-HLA typing sera specific for either class I and class II molecules revealed that 46% (19/41) of these sera contained cross-reactive antibodies to HIV-1 proteins. Absorption of measles sera with mixed lymphocyte reaction (MLR)-activated lymphocytes and/or HIV-1 recombinant proteins significantly decreased or removed the presence of these HIV-1- immunoreactive antibodies. Together, these findings suggest that the immune response to a natural measles virus infection results in the production of antibodies to HIV-1 and possibly autoantigens.

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Serum antibodies to HIV-1 are produced post-measles virus infection: Evidence for cross-reactivity with HLA

Abstract

Keywords

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