Serum antibodies to HIV-1 are produced post-measles virus infection: Evidence for cross-reactivity with HLA

P. V. Baskar, G. D. Collins, B. A. Dorsey-Cooper, R. S. Pyle, J. E. Nagel, D. Dwyer, G. Dunston, C. E. Johnson, N. Kendig, E. Israel, D. R. Nalin, W. H. Adler

Research output: Contribution to journalArticle

Abstract

Convalescent sera obtained from patients who were recently recovered from an acute measles virus infection were tested for the presence of anti- HIV-1 antibodies by Western blot analysis. While 16% (17/104) of control sera displayed reactive bands to a variety of HIV proteins, 62% (45/73) of convalescent sera demonstrated immunoreactive bands corresponding to HIV-1 Pol and Gag, but not Env antigens. This cross-reactivity appears to be the result of an active measles infection. No HIV-1 immunoblot reactivity (0/10) was observed in sera obtained from young adults several weeks after a combined measles, mumps, and rubella (MMR) vaccination. Interestingly, examination of anti-HLA typing sera specific for either class I and class II molecules revealed that 46% (19/41) of these sera contained cross-reactive antibodies to HIV-1 proteins. Absorption of measles sera with mixed lymphocyte reaction (MLR)-activated lymphocytes and/or HIV-1 recombinant proteins significantly decreased or removed the presence of these HIV-1- immunoreactive antibodies. Together, these findings suggest that the immune response to a natural measles virus infection results in the production of antibodies to HIV-1 and possibly autoantigens.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalClinical and Experimental Immunology
Volume111
Issue number2
DOIs
StatePublished - Mar 9 1998
Externally publishedYes

Keywords

  • HIV-1
  • Indeterminate Western blot
  • Measles

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Baskar, P. V., Collins, G. D., Dorsey-Cooper, B. A., Pyle, R. S., Nagel, J. E., Dwyer, D., Dunston, G., Johnson, C. E., Kendig, N., Israel, E., Nalin, D. R., & Adler, W. H. (1998). Serum antibodies to HIV-1 are produced post-measles virus infection: Evidence for cross-reactivity with HLA. Clinical and Experimental Immunology, 111(2), 251-256. https://doi.org/10.1046/j.1365-2249.1998.00488.x