Serum antibodies to Epstein-Barr virus in patients with major depressive disorder

J. D. Amsterdam, W. Henle, A. Winokur, O. M. Wolkowitz, D. Pickar, S. M. Paul

Research output: Contribution to journalArticle

Abstract

To determine whether major depressive disorder might be associated with serologic evidence for a chronic active Epstein-Barr virus infection, viral-specific antibodies were measured in two separate groups of depressed patients (N = 43) and in 46 appropriately matched healthy volunteers. No evidence that depression affects cellular immunity to the point that a persistent Epstein-Barr virus carrier state becomes activated was found. There was also no evidence that depression results from an unrecognized chronic active Epstein-Barr virus infection. The authors conclude that the routine clinical determination of expensive commercial Epstein-Barr virus antibody profiles is not indicated in most patients with major depressive disorder in the absence of other signs of chronic active Epstein-Barr viral infection.

Original languageEnglish (US)
Pages (from-to)1593-1596
Number of pages4
JournalAmerican Journal of Psychiatry
Volume143
Issue number12
StatePublished - 1986
Externally publishedYes

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Epstein-Barr Virus Infections
Major Depressive Disorder
Human Herpesvirus 4
Viral Antibodies
Depression
Carrier State
Antibodies
Virus Diseases
Serum
Cellular Immunity
Healthy Volunteers

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Amsterdam, J. D., Henle, W., Winokur, A., Wolkowitz, O. M., Pickar, D., & Paul, S. M. (1986). Serum antibodies to Epstein-Barr virus in patients with major depressive disorder. American Journal of Psychiatry, 143(12), 1593-1596.

Serum antibodies to Epstein-Barr virus in patients with major depressive disorder. / Amsterdam, J. D.; Henle, W.; Winokur, A.; Wolkowitz, O. M.; Pickar, D.; Paul, S. M.

In: American Journal of Psychiatry, Vol. 143, No. 12, 1986, p. 1593-1596.

Research output: Contribution to journalArticle

Amsterdam, JD, Henle, W, Winokur, A, Wolkowitz, OM, Pickar, D & Paul, SM 1986, 'Serum antibodies to Epstein-Barr virus in patients with major depressive disorder', American Journal of Psychiatry, vol. 143, no. 12, pp. 1593-1596.
Amsterdam JD, Henle W, Winokur A, Wolkowitz OM, Pickar D, Paul SM. Serum antibodies to Epstein-Barr virus in patients with major depressive disorder. American Journal of Psychiatry. 1986;143(12):1593-1596.
Amsterdam, J. D. ; Henle, W. ; Winokur, A. ; Wolkowitz, O. M. ; Pickar, D. ; Paul, S. M. / Serum antibodies to Epstein-Barr virus in patients with major depressive disorder. In: American Journal of Psychiatry. 1986 ; Vol. 143, No. 12. pp. 1593-1596.
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