Serum antibodies reactive with non-human primate retroviruses identified in acute onset schizophrenia

E. P. Lillehoj, G. M. Ford, S. Bachmann, J. Schröder, E. F. Torrey, Robert H Yolken

Research output: Contribution to journalArticle

Abstract

Schizophrenia is a pervasive neuropsychiatric disease of uncertain etiology. Previous studies have postulated that retroviruses may contribute to the etiology of some cases of schizophrenia. We examined the possible relationship between retroviral infection and schizophrenia by measuring antibodies to a number of different primate retroviruses in the sera of individuals undergoing their first hospitalization for this disease. Sera from patients with first onset schizophrenia and matched healthy controls were analyzed by immunoblot and enzyme linked immunosorbent assays using purified retrovirus antigens to identify and quantify antibodies reactive with retrovirus proteins. A significantly increased incidence of antibodies reactive to gag encoded proteins of Mason-Pfizer monkey virus (MPMV), baboon endogenous virus (BaEV) and simian retrovirus type 5 (SRV-5) was observed in the sera of schizophrenia patients compared to controls. The reactivity of the cases and controls displayed the greatest differences in terms of antibodies to the proteins of Mason-Pfizer monkey virus. Employing an algorithm of enzyme linked immunosorbent assay reactivity followed by immunoblot confirmation, we found that MPMV antibodies in 28.9% of the individuals with first episode schizophrenia patients as compared to 3.7% of the unaffected controls (P

Original languageEnglish (US)
Pages (from-to)492-497
Number of pages6
JournalJournal of NeuroVirology
Volume6
Issue number6
StatePublished - 2000

Fingerprint

Retroviridae
Primates
Schizophrenia
Mason-Pfizer monkey virus
Antibodies
Serum
Simian Retroviruses
Retroviridae Proteins
Enzyme-Linked Immunosorbent Assay
Endogenous Retroviruses
gag Gene Products
Papio
Hospitalization
Viruses
Antigens
Incidence
Infection
Proteins

Keywords

  • ELISA
  • Gag
  • Immunoblot
  • Protein
  • Retrovirus
  • Schizophrenia

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology

Cite this

Lillehoj, E. P., Ford, G. M., Bachmann, S., Schröder, J., Torrey, E. F., & Yolken, R. H. (2000). Serum antibodies reactive with non-human primate retroviruses identified in acute onset schizophrenia. Journal of NeuroVirology, 6(6), 492-497.

Serum antibodies reactive with non-human primate retroviruses identified in acute onset schizophrenia. / Lillehoj, E. P.; Ford, G. M.; Bachmann, S.; Schröder, J.; Torrey, E. F.; Yolken, Robert H.

In: Journal of NeuroVirology, Vol. 6, No. 6, 2000, p. 492-497.

Research output: Contribution to journalArticle

Lillehoj, EP, Ford, GM, Bachmann, S, Schröder, J, Torrey, EF & Yolken, RH 2000, 'Serum antibodies reactive with non-human primate retroviruses identified in acute onset schizophrenia', Journal of NeuroVirology, vol. 6, no. 6, pp. 492-497.
Lillehoj, E. P. ; Ford, G. M. ; Bachmann, S. ; Schröder, J. ; Torrey, E. F. ; Yolken, Robert H. / Serum antibodies reactive with non-human primate retroviruses identified in acute onset schizophrenia. In: Journal of NeuroVirology. 2000 ; Vol. 6, No. 6. pp. 492-497.
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