Serum androgen and gonadotropin levels decline after progestogen-induced withdrawal bleeding in oligomenorrheic women with or without polycystic ovaries

L. Anttila, P. Koskinen, H. L. Kaihola, R. Erkkola, K. Irjala, K. Ruutiainen

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To examine the effect of short-term progestogen treatment on androgen, gonadotropin, and sex hormone-binding globulin (SHBG) levels in oligomenorrheic women. Design: Comparative study of changes in hormonal parameters in patients with or without ultrasonographically diagnosed polycystic ovarian disease (PCOD). Setting: Open patient clinic of reproductive endocrinology at University Central Hospital of Turku, Finland. Patients: Seventy-five oligomenorrheic women with (n = 51) or without (n = 24) PCOD. Main Outcome Measures: Serum concentrations of testosterone (T), androstenedione (A), dehydroepiandrosterone sulfate, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and SHBG. Results: The levels of T, A, LH, and the LH:FSH ratios decreased significantly after oral treatment with medroxyprogesterone acetate (10 mg/d for 10 days) in non-PCOD women and in women with PCOD decreasing the frequencies of pathological laboratory findings, in particular elevated levels of LH:FSH ratio and A in PCOD women and of LH:FSH ratio in non-PCOD women. The levels of T, A, and LH as well as the LH:FSH ratio were significantly higher in women with PCOD. Obesity was associated with high free androgen indices, low LH:FSH ratios, and low concentrations of LH, A, and SHBG. Conclusions: The serum samples for hormonal analyses used as an aid in diagnosing PCOD should be obtained without pretreatment with progestogen because it masks the biochemical findings of PCOD.

Original languageEnglish (US)
Pages (from-to)697-702
Number of pages6
JournalFertility and sterility
Volume58
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • Polycystic ovarian disease
  • androgens
  • gonadotropins
  • medroxyprogesterone acetate
  • oligomenorrhea

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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