TY - JOUR
T1 - Serum and plasma markers of nutritional status in children infected with the human immunodeficiency virus
AU - Henderson, Robin A.
AU - Talusan, Karen
AU - Hutton, Nancy
AU - Yolken, Robert H.
AU - Caballero, Benjamin
N1 - Funding Information:
This study was supported, in part, by Pediatric AIDS Foundation Scholar Award, National Institutes of Health RR-00052, and NIH U01AI2756506.
PY - 1997
Y1 - 1997
N2 - Objective: To determine whether reduced serum or plasma protein and micronutrient levels are common in children infected with the human immunodeficiency virus (HIV) and whether these levels are different in children with growth retardation compared to those with normal growth. Subjects: Children were separated into three groups: (a) HIV-infected with growth retardation (HIV+Gr); (b) HIV-infected with normal growth (HIV+); (c) HIV-uninfected with normal growth (HIV-). All children were afebrile and free of acute infection at the time of study. During a 24-hour stay in the Pediatric Clinical Research Unit, blood was drawn for analysis of total protein, album, zinc, selenium, and vitamin A levels; growth measurements were obtained; and dietary intake was assessed by 24-hour weighed food intake and 24-hour dietary recall. Statistical analysis: Mean differences between groups were assessed by analysis of variance, and differences in the frequency of nutrient deficiency were determined by χ2 analysis. Results: Thirty-eight children between 2 and 11 years of age were studied: 10 HIV+Gr, 18 HIV+, and 10 HIV-. No statistically significantly differences were noted in mean levels of albumin, prealbumin, zinc, and selenium. Mean serum level of vitamin A was significantly higher in the HIV+Gr group than in the other two groups. There were no significant differences between groups in the frequency of deficiency for any nutrient studied. Mean energy and nutrient intake was similar among groups. Applications/conclusions: Abnormal serum or plasma protein or micronutrient levels were uncommon in this cohort of HIV- infected children, even in children with growth retardation. Routine monitoring of the level of proteins and micronutrients studied is unnecessary in the absence of specific clinical indicators of deficiency.
AB - Objective: To determine whether reduced serum or plasma protein and micronutrient levels are common in children infected with the human immunodeficiency virus (HIV) and whether these levels are different in children with growth retardation compared to those with normal growth. Subjects: Children were separated into three groups: (a) HIV-infected with growth retardation (HIV+Gr); (b) HIV-infected with normal growth (HIV+); (c) HIV-uninfected with normal growth (HIV-). All children were afebrile and free of acute infection at the time of study. During a 24-hour stay in the Pediatric Clinical Research Unit, blood was drawn for analysis of total protein, album, zinc, selenium, and vitamin A levels; growth measurements were obtained; and dietary intake was assessed by 24-hour weighed food intake and 24-hour dietary recall. Statistical analysis: Mean differences between groups were assessed by analysis of variance, and differences in the frequency of nutrient deficiency were determined by χ2 analysis. Results: Thirty-eight children between 2 and 11 years of age were studied: 10 HIV+Gr, 18 HIV+, and 10 HIV-. No statistically significantly differences were noted in mean levels of albumin, prealbumin, zinc, and selenium. Mean serum level of vitamin A was significantly higher in the HIV+Gr group than in the other two groups. There were no significant differences between groups in the frequency of deficiency for any nutrient studied. Mean energy and nutrient intake was similar among groups. Applications/conclusions: Abnormal serum or plasma protein or micronutrient levels were uncommon in this cohort of HIV- infected children, even in children with growth retardation. Routine monitoring of the level of proteins and micronutrients studied is unnecessary in the absence of specific clinical indicators of deficiency.
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U2 - 10.1016/S0002-8223(97)00333-7
DO - 10.1016/S0002-8223(97)00333-7
M3 - Article
C2 - 9404333
AN - SCOPUS:0031459484
SN - 0002-8223
VL - 97
SP - 1377
EP - 1381
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
IS - 12
ER -