Serum amyloid A1 (SAA1) protein in human colostrum

George Henry Sack, Natasha E Zachara, Nadine Rosenblum, C. Conover Talbot, Simion Kreimer, Robert N Cole, Thomas L. Mcdonald

Research output: Contribution to journalArticle

Abstract

Proteins of the serum amyloid A (SAA) family have been remarkably conserved in evolution. Their biologic function(s) are not fully defined but they are likely to be a part of primordial host defense. We have detected a ∼ 12-kDa protein reacting with antibodies against serum amyloid A (SAA) in human colostrum by western blotting. Mass spectrometry identified the reactive species as SAA1, previously identified as a prominent member of the acute-phase response in serum. Our finding SAA1 in human colostrum contrasts with bovine, caprine and ovine colostrum where a species corresponding to putative SAA3 is uniformly present. SAA1 protein in human colostrum presumably contributes to neonatal protection.

Original languageEnglish (US)
JournalFEBS Open Bio
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Keywords

  • Acute-phase
  • Amyloid
  • Colostrum
  • Serum amyloid A

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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