Serum Amyloid A (SAA) Proteins

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

As normal constituents of blood serum, the Serum Amyloid A (SAA) proteins are small (104 amino acids in humans) and remarkably well-conserved in mammalian evolution. They are synthesized prominently, but not exclusively, in the liver. Fragments of SAA can associate into insoluble fibrils (called “amyloid”) characteristic of “secondary” amyloid disease in which they can interrupt normal physiology and lead to organ failure. SAA proteins comprise a family of molecules, two members of which (SAA1 and SAA2) are (along with C-reactive protein, CRP) the most prominent members of the acute phase response (APR) during which their serum levels rise dramatically after trauma, infection and other stimuli. Biologic function(s) of SAA are unresolved but features are consistent with a prominent role in primordial host defense (including the APR). SAA proteins are lipophilic and contribute to high density lipoproteins (HDL) and cholesterol transport. SAA proteins interact with specific receptors and have been implicated in tissue remodeling through metalloproteinases, local tissue changes in atherosclerosis, cancer metastasis, lung inflammation, maternal–fetal health and intestinal physiology. Molecular details of some of these are emerging.

Original languageEnglish (US)
Title of host publicationSubcellular Biochemistry
PublisherSpringer
Pages421-436
Number of pages16
DOIs
StatePublished - 2020

Publication series

NameSubcellular Biochemistry
Volume94
ISSN (Print)0306-0225

Keywords

  • APR
  • Acute phase reaction
  • Amyloidosis
  • Arthritis
  • Atherosclerosis
  • Cytokine
  • HDL
  • Inflammation
  • Lipoproteins
  • Metastasis
  • SAA
  • Serum amyloid A

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Serum Amyloid A (SAA) Proteins'. Together they form a unique fingerprint.

Cite this