Serum amyloid A gene transcription in synovial cells during retroviral arthritis

Research output: Contribution to journalArticle

Abstract

In situ hybridization was used to demonstrate serum amyloid A (SAA) gene expression in arthritic joint tissue from lentivirus-infected sheep and goats. SAA gene transcription occurs in isolated individual synovial cells and occasional giant cells but not in uninfected or uninflamed synovial tissue. These findings support the notion (derived from in vitro observations) that at least one member of the SAA gene/ protein family may function as an autocrine collagenase inducer in inflammatory arthritis. Since we used heterologous DNA probes derived from human clones, our findings also support the growing evidence for interspecies conservation of SAA genes.

Original languageEnglish (US)
Pages (from-to)525-529
Number of pages5
JournalAmerican Journal of Pathology
Volume141
Issue number3
StatePublished - Sep 1992

Fingerprint

Serum Amyloid A Protein
Arthritis
vif Genes
Genes
Lentivirus
DNA Probes
Collagenases
Giant Cells
Amyloid
Goats
In Situ Hybridization
Sheep
Clone Cells
Joints
Gene Expression
Serum
Proteins

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Serum amyloid A gene transcription in synovial cells during retroviral arthritis. / Sack, George Henry; Zink, Mary Christine.

In: American Journal of Pathology, Vol. 141, No. 3, 09.1992, p. 525-529.

Research output: Contribution to journalArticle

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