Serum amyloid A - a review

Research output: Contribution to journalReview article

Abstract

Serum amyloid A (SAA) proteins were isolated and named over 50 years ago. They are small (104 amino acids) and have a striking relationship to the acute phase response with serum levels rising as much as 1000-fold in 24 hours. SAA proteins are encoded in a family of closely-related genes and have been remarkably conserved throughout vertebrate evolution. Amino-terminal fragments of SAA can form highly organized, insoluble fibrils that accumulate in "secondary" amyloid disease. Despite their evolutionary preservation and dynamic synthesis pattern SAA proteins have lacked well-defined physiologic roles. However, considering an array of many, often unrelated, reports now permits a more coordinated perspective. Protein studies have elucidated basic SAA structure and fibril formation. Appreciating SAA's lipophilicity helps relate it to lipid transport and metabolism as well as atherosclerosis. SAA's function as a cytokine-like protein has become recognized in cell-cell communication as well as feedback in inflammatory, immunologic, neoplastic and protective pathways. SAA likely has a critical role in control and possibly propagation of the primordial acute phase response. Appreciating the many cellular and molecular interactions for SAA suggests possibilities for improved understanding of pathophysiology as well as treatment and disease prevention.

Original languageEnglish (US)
Number of pages1
JournalMolecular medicine (Cambridge, Mass.)
Volume24
Issue number1
DOIs
StatePublished - Aug 30 2018

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Serum Amyloid A Protein
Acute-Phase Reaction
Lipid Metabolism
Amyloid
Cell Communication
Vertebrates
Atherosclerosis
Proteins
Cytokines
Amino Acids
Serum

Keywords

  • acute phase response (APR)
  • amyloidosis
  • apolipoprotein
  • arthritis
  • atherosclerosis
  • cytokine
  • inflammation
  • lipopolysaccharide (LPS)
  • liver
  • myeloid-derived suppressor cells (MDSC)
  • SAA
  • Serum amyloid A

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Serum amyloid A - a review. / Sack, George Henry.

In: Molecular medicine (Cambridge, Mass.), Vol. 24, No. 1, 30.08.2018.

Research output: Contribution to journalReview article

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