Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study

Wassim W. Labaki, Tian Gu, Susan Murray, Jeffrey L. Curtis, Larisa Yeomans, Russell P. Bowler, R. Graham Barr, Alejandro P. Comellas, Nadia N. Hansel, Christopher B. Cooper, Igor Barjaktarevic, Richard E. Kanner, Robert Paine, Merry Lynn N. McDonald, Jerry A. Krishnan, Stephen P. Peters, Prescott G. Woodruff, Wanda K. O’Neal, Wenqi Diao, Bei HeFernando J. Martinez, Theodore J. Standiford, Kathleen A. Stringer, Mei Lan K. Han

Research output: Contribution to journalArticle

Abstract

Metabolomics is an emerging science that can inform pathogenic mechanisms behind clinical phenotypes in COPD. We aimed to understand disturbances in the serum metabolome associated with respiratory outcomes in ever-smokers from the SPIROMICS cohort. We measured 27 serum metabolites, mostly amino acids, by 1H-nuclear magnetic resonance spectroscopy in 157 white ever-smokers with and without COPD. We tested the association between log-transformed metabolite concentrations and one-year incidence of respiratory exacerbations after adjusting for age, sex, current smoking, body mass index, diabetes, inhaled or oral corticosteroid use, study site and clinical predictors of exacerbations, including FEV1% predicted and history of exacerbations. The mean age of participants was 53.7 years and 58% had COPD. Lower concentrations of serum amino acids were independently associated with 1-year incidence of respiratory exacerbations, including tryptophan (β = −4.1, 95% CI [−7.0; −1.1], p = 0.007) and the branched-chain amino acids (leucine: β = −6.0, 95% CI [−9.5; −2.4], p = 0.001; isoleucine: β = −5.2, 95% CI [−8.6; −1.8], p = 0.003; valine: β = −4.1, 95% CI [−6.9; −1.4], p = 0.003). Tryptophan concentration was inversely associated with the blood neutrophil-to-lymphocyte ratio (p = 0.03) and the BODE index (p = 0.03). Reduced serum amino acid concentrations in ever-smokers with and without COPD are associated with an increased incidence of respiratory exacerbations.

Original languageEnglish (US)
Article number11367
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study'. Together they form a unique fingerprint.

  • Cite this

    Labaki, W. W., Gu, T., Murray, S., Curtis, J. L., Yeomans, L., Bowler, R. P., Barr, R. G., Comellas, A. P., Hansel, N. N., Cooper, C. B., Barjaktarevic, I., Kanner, R. E., Paine, R., McDonald, M. L. N., Krishnan, J. A., Peters, S. P., Woodruff, P. G., O’Neal, W. K., Diao, W., ... Han, M. L. K. (2019). Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study. Scientific reports, 9(1), [11367]. https://doi.org/10.1038/s41598-019-47761-w