TY - JOUR
T1 - Serum Adiponectin Levels, Neuroimaging, and Cognition in the Mayo Clinic Study of Aging
AU - Wennberg, Alexandra M V
AU - Gustafson, Deborah
AU - Hagen, Clinton E.
AU - Roberts, Rosebud O.
AU - Knopman, David
AU - Jack, Clifford
AU - Petersen, Ronald C.
AU - Mielke, Michelle M.
AU - Bowman, Gene
PY - 2016
Y1 - 2016
N2 - Background: Adiponectin, a protein involved in inflammatory pathways, may impact the development and progression of Alzheimer's disease (AD). Adiponectin levels have been associated with mild cognitive impairment (MCI) and AD; however, its association with Alzheimer-associated neuroimaging and cognitive outcomes is unknown. Objective: Determine the cross-sectional association between plasma adiponectin and neuroimaging and cognitive outcomes in an older population-based sample. Methods: Multivariable adjusted regression models were used to investigate the association between plasma adiponectin and hippocampal volume (HVa), PiB-PET, FDG PET, cortical thickness, MCI diagnosis, and neuropsychological test performance. Analyses included 535 non-demented participants aged 70 and older enrolled in the Mayo Clinic Study of Aging. Results: Women had higher adiponectin than men (12,631ng/mL versus 8,908ng/mL, p1.4), among women with elevated amyloid, higher adiponectin was associated with smaller HVa (B=-0.723; 95 CI -1.43, -0.014), poorer performance in memory (B=-1.02; 95 CI -1.73, -0.312), language (B=-0.896; 95 CI -1.58, -0.212), global cognition (B=-0.650; 95 CI -1.18, -0.116), and greater odds of MCI (OR=19.34; 95 CI 2.72, 137.34). Conclusion: Higher plasma adiponectin was associated with neuroimaging and cognitive outcomes among women. Longitudinal analyses are necessary to determine whether higher adiponectin predicts neurodegeneration and cognitive decline.
AB - Background: Adiponectin, a protein involved in inflammatory pathways, may impact the development and progression of Alzheimer's disease (AD). Adiponectin levels have been associated with mild cognitive impairment (MCI) and AD; however, its association with Alzheimer-associated neuroimaging and cognitive outcomes is unknown. Objective: Determine the cross-sectional association between plasma adiponectin and neuroimaging and cognitive outcomes in an older population-based sample. Methods: Multivariable adjusted regression models were used to investigate the association between plasma adiponectin and hippocampal volume (HVa), PiB-PET, FDG PET, cortical thickness, MCI diagnosis, and neuropsychological test performance. Analyses included 535 non-demented participants aged 70 and older enrolled in the Mayo Clinic Study of Aging. Results: Women had higher adiponectin than men (12,631ng/mL versus 8,908ng/mL, p1.4), among women with elevated amyloid, higher adiponectin was associated with smaller HVa (B=-0.723; 95 CI -1.43, -0.014), poorer performance in memory (B=-1.02; 95 CI -1.73, -0.312), language (B=-0.896; 95 CI -1.58, -0.212), global cognition (B=-0.650; 95 CI -1.18, -0.116), and greater odds of MCI (OR=19.34; 95 CI 2.72, 137.34). Conclusion: Higher plasma adiponectin was associated with neuroimaging and cognitive outcomes among women. Longitudinal analyses are necessary to determine whether higher adiponectin predicts neurodegeneration and cognitive decline.
KW - Adiponectin
KW - Amyloid-PET
KW - Cognition
KW - FDG-PET
KW - Hippocampal volume
KW - Mild cognitive impairment
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U2 - 10.3233/JAD-151201
DO - 10.3233/JAD-151201
M3 - Article
AN - SCOPUS:84979239899
SN - 1387-2877
VL - 53
SP - 573
EP - 581
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 2
ER -