Serum adiponectin during pregnancy and postpartum in women with gestational diabetes and normal controls

Nikolaos Vitoratos, Aikaterini Deliveliotou, Nikos F. Vlahos, George Mastorakos, Konstantinos Papadias, Dimitrios Botsis, George K. Creatsas

    Research output: Contribution to journalArticle

    Abstract

    Aims. To investigate changes in serum adiponectin during pregnancy and postpartum and assess its relationship with insulin resistance as measured by homeostasis model assessment (HOMA-IR). Methods. Twenty-two normal pregnant women were compared with 22 women diagnosed with gestational diabetes mellitus (GDM). Serum adiponectin levels were measured at the time of the glucose challenge test as well as in the immediate postpartum period and the correlation of adiponectin to HOMA-IR was performed. Results. Adiponectin was significantly lower in women with GDM than in controls during pregnancy (5381 vs. 8449 ng/dl, p = 0.004), as well as postpartum (3278 vs. 6958 ng/ml, p = 0.002). A significant reduction in adiponectin (3278 vs. 5381 ng/ml, p = 0.002) was observed postpartum in GDM women but not in controls. Using a lower cut-off value of 5253 ng/ml, maternal adiponectin could exclude GDM with a sensitivity of 86.4% and a specificity of 59.1% (area under the curve = 0.752, standard error = 0.77, 95% confidence interval 0.601-0.903, p = 0.004). Adiponectin levels during pregnancy were negatively correlated with HOMA-IR (r = -0.375, p = 0.012). Conclusion. GDM is associated with decreased serum adiponectin levels both in pregnancy as well as postpartum. Adiponectin is negatively correlated to HOMA-IR. A reduction in maternal adiponectin after delivery indicates a significant placental contribution to adiponectin production.

    Original languageEnglish (US)
    Pages (from-to)614-619
    Number of pages6
    JournalGynecological Endocrinology
    Volume24
    Issue number11
    DOIs
    StatePublished - Dec 1 2008

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    Keywords

    • Adiponectin
    • Gestational diabetes
    • Homeostasis model assessment
    • Insulin resistance

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology
    • Obstetrics and Gynecology

    Cite this

    Vitoratos, N., Deliveliotou, A., Vlahos, N. F., Mastorakos, G., Papadias, K., Botsis, D., & Creatsas, G. K. (2008). Serum adiponectin during pregnancy and postpartum in women with gestational diabetes and normal controls. Gynecological Endocrinology, 24(11), 614-619. https://doi.org/10.1080/09513590802342866