Serum adiponectin complexes and cardiovascular risk in children with chronic kidney disease

Megan M. Lo, Shelia Salisbury, Philipp E. Scherer, Susan L. Furth, Bradley A. Warady, Mark M. Mitsnefes

Research output: Contribution to journalArticle

Abstract

In contrast to the general population, patients with chronic kidney disease (CKD) experience increased total adiponectin levels despite an increased prevalence of cardiovascular disease. Adiponectin circulates as trimer, low molecular weight (LMW), and high molecular weight (HMW) complexes. The distribution and role of each subfraction in CKD is unknown. This cross-sectional analysis examined the association of serum adiponectin and its subfractions with known cardiovascular risk factors in 105 children (median age 12 years; 56% male) enrolled into the Chronic Kidney Disease in Children (CKiD) study, an observational cohort study of children with CKD stage 2-4. HMW accounted for 46% of total adiponectin, followed by LMW (34%) and trimer (20%). In multivariable analysis, LMW was independently associated with iohexol glomerular filtration rate (GFR) (p=0.004) and was higher in pubertal versus prepubertal children (p=0.005). HMW/LMW ratio was independently associated with age and iohexol GFR (all p

Original languageEnglish (US)
Pages (from-to)2009-2017
Number of pages9
JournalPediatric Nephrology
Volume26
Issue number11
DOIs
StatePublished - Nov 2011
Externally publishedYes

Fingerprint

Adiponectin
Chronic Renal Insufficiency
Molecular Weight
Serum
Iohexol
Glomerular Filtration Rate
Observational Studies
Cohort Studies
Cardiovascular Diseases
Cross-Sectional Studies
Population

Keywords

  • Adiponectin
  • Cardiovascular disease
  • Children
  • CKD

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Lo, M. M., Salisbury, S., Scherer, P. E., Furth, S. L., Warady, B. A., & Mitsnefes, M. M. (2011). Serum adiponectin complexes and cardiovascular risk in children with chronic kidney disease. Pediatric Nephrology, 26(11), 2009-2017. https://doi.org/10.1007/s00467-011-1906-x

Serum adiponectin complexes and cardiovascular risk in children with chronic kidney disease. / Lo, Megan M.; Salisbury, Shelia; Scherer, Philipp E.; Furth, Susan L.; Warady, Bradley A.; Mitsnefes, Mark M.

In: Pediatric Nephrology, Vol. 26, No. 11, 11.2011, p. 2009-2017.

Research output: Contribution to journalArticle

Lo, MM, Salisbury, S, Scherer, PE, Furth, SL, Warady, BA & Mitsnefes, MM 2011, 'Serum adiponectin complexes and cardiovascular risk in children with chronic kidney disease', Pediatric Nephrology, vol. 26, no. 11, pp. 2009-2017. https://doi.org/10.1007/s00467-011-1906-x
Lo, Megan M. ; Salisbury, Shelia ; Scherer, Philipp E. ; Furth, Susan L. ; Warady, Bradley A. ; Mitsnefes, Mark M. / Serum adiponectin complexes and cardiovascular risk in children with chronic kidney disease. In: Pediatric Nephrology. 2011 ; Vol. 26, No. 11. pp. 2009-2017.
@article{654196731b704eb7884ea73d3b2dcf82,
title = "Serum adiponectin complexes and cardiovascular risk in children with chronic kidney disease",
abstract = "In contrast to the general population, patients with chronic kidney disease (CKD) experience increased total adiponectin levels despite an increased prevalence of cardiovascular disease. Adiponectin circulates as trimer, low molecular weight (LMW), and high molecular weight (HMW) complexes. The distribution and role of each subfraction in CKD is unknown. This cross-sectional analysis examined the association of serum adiponectin and its subfractions with known cardiovascular risk factors in 105 children (median age 12 years; 56{\%} male) enrolled into the Chronic Kidney Disease in Children (CKiD) study, an observational cohort study of children with CKD stage 2-4. HMW accounted for 46{\%} of total adiponectin, followed by LMW (34{\%}) and trimer (20{\%}). In multivariable analysis, LMW was independently associated with iohexol glomerular filtration rate (GFR) (p=0.004) and was higher in pubertal versus prepubertal children (p=0.005). HMW/LMW ratio was independently associated with age and iohexol GFR (all p",
keywords = "Adiponectin, Cardiovascular disease, Children, CKD",
author = "Lo, {Megan M.} and Shelia Salisbury and Scherer, {Philipp E.} and Furth, {Susan L.} and Warady, {Bradley A.} and Mitsnefes, {Mark M.}",
year = "2011",
month = "11",
doi = "10.1007/s00467-011-1906-x",
language = "English (US)",
volume = "26",
pages = "2009--2017",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer Verlag",
number = "11",

}

TY - JOUR

T1 - Serum adiponectin complexes and cardiovascular risk in children with chronic kidney disease

AU - Lo, Megan M.

AU - Salisbury, Shelia

AU - Scherer, Philipp E.

AU - Furth, Susan L.

AU - Warady, Bradley A.

AU - Mitsnefes, Mark M.

PY - 2011/11

Y1 - 2011/11

N2 - In contrast to the general population, patients with chronic kidney disease (CKD) experience increased total adiponectin levels despite an increased prevalence of cardiovascular disease. Adiponectin circulates as trimer, low molecular weight (LMW), and high molecular weight (HMW) complexes. The distribution and role of each subfraction in CKD is unknown. This cross-sectional analysis examined the association of serum adiponectin and its subfractions with known cardiovascular risk factors in 105 children (median age 12 years; 56% male) enrolled into the Chronic Kidney Disease in Children (CKiD) study, an observational cohort study of children with CKD stage 2-4. HMW accounted for 46% of total adiponectin, followed by LMW (34%) and trimer (20%). In multivariable analysis, LMW was independently associated with iohexol glomerular filtration rate (GFR) (p=0.004) and was higher in pubertal versus prepubertal children (p=0.005). HMW/LMW ratio was independently associated with age and iohexol GFR (all p

AB - In contrast to the general population, patients with chronic kidney disease (CKD) experience increased total adiponectin levels despite an increased prevalence of cardiovascular disease. Adiponectin circulates as trimer, low molecular weight (LMW), and high molecular weight (HMW) complexes. The distribution and role of each subfraction in CKD is unknown. This cross-sectional analysis examined the association of serum adiponectin and its subfractions with known cardiovascular risk factors in 105 children (median age 12 years; 56% male) enrolled into the Chronic Kidney Disease in Children (CKiD) study, an observational cohort study of children with CKD stage 2-4. HMW accounted for 46% of total adiponectin, followed by LMW (34%) and trimer (20%). In multivariable analysis, LMW was independently associated with iohexol glomerular filtration rate (GFR) (p=0.004) and was higher in pubertal versus prepubertal children (p=0.005). HMW/LMW ratio was independently associated with age and iohexol GFR (all p

KW - Adiponectin

KW - Cardiovascular disease

KW - Children

KW - CKD

UR - http://www.scopus.com/inward/record.url?scp=83155175423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83155175423&partnerID=8YFLogxK

U2 - 10.1007/s00467-011-1906-x

DO - 10.1007/s00467-011-1906-x

M3 - Article

C2 - 21553321

AN - SCOPUS:83155175423

VL - 26

SP - 2009

EP - 2017

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 11

ER -