TY - JOUR
T1 - Serum adipokine and inflammatory markers before and after liver transplantation in recipients with major cardiovascular events
AU - Watt, Kymberly D.
AU - Fan, Chun
AU - Therneau, Terry
AU - Heimbach, Julie K.
AU - Seaberg, Eric C.
AU - Charlton, Michael R.
PY - 2014/7
Y1 - 2014/7
N2 - In the nontransplant setting, aberrant serum adipokine levels are associated with cardiovascular (CV) disease. The effects of liver transplantation (LT) on serum adipokine levels and their association with post-LT CV disease have not been studied. A nested case-control study of 77 patients with major CV events more than 4 months after LT analyzed serum adiponectin, resistin, leptin, C-reactive protein, and apolipoprotein levels measured before transplantation and 4, 12, and 24 months after LT. Adiponectin and resistin levels decreased dramatically after LT in all patients. Recipients with CV disease had lower levels of adiponectin and higher levels of resistin, leptin, C-reactive protein, and apolipoprotein B100 than controls. The pre-LT adiponectin level was associated with a 16% increased risk for CV events for every 1 μg/mL decrease in adiponectin [hazard ratio (HR)=0.84, P=0.046]. Pre-LT C-reactive protein levels (HR=1.03, P=0.047) and 12-month C-reactive protein levels (HR=1.03, P=0.03) were associated with CV events after LT. Pre-LT Diabetes (HR=2.14, P=0.09), and post-LT resistin (HR=1.07, P=0.07), and apolipoprotein B (HR=1.08, P=0.08) were associated with a nonsignificantly increased risk of CV events in this small sample size. In conclusion, pre- and post-LT changes in serum adipokine and inflammatory markers may be signals of an increased risk of CV events after LT, but further study is needed. Liver Transpl 20:791-797, 2014.
AB - In the nontransplant setting, aberrant serum adipokine levels are associated with cardiovascular (CV) disease. The effects of liver transplantation (LT) on serum adipokine levels and their association with post-LT CV disease have not been studied. A nested case-control study of 77 patients with major CV events more than 4 months after LT analyzed serum adiponectin, resistin, leptin, C-reactive protein, and apolipoprotein levels measured before transplantation and 4, 12, and 24 months after LT. Adiponectin and resistin levels decreased dramatically after LT in all patients. Recipients with CV disease had lower levels of adiponectin and higher levels of resistin, leptin, C-reactive protein, and apolipoprotein B100 than controls. The pre-LT adiponectin level was associated with a 16% increased risk for CV events for every 1 μg/mL decrease in adiponectin [hazard ratio (HR)=0.84, P=0.046]. Pre-LT C-reactive protein levels (HR=1.03, P=0.047) and 12-month C-reactive protein levels (HR=1.03, P=0.03) were associated with CV events after LT. Pre-LT Diabetes (HR=2.14, P=0.09), and post-LT resistin (HR=1.07, P=0.07), and apolipoprotein B (HR=1.08, P=0.08) were associated with a nonsignificantly increased risk of CV events in this small sample size. In conclusion, pre- and post-LT changes in serum adipokine and inflammatory markers may be signals of an increased risk of CV events after LT, but further study is needed. Liver Transpl 20:791-797, 2014.
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U2 - 10.1002/lt.23880
DO - 10.1002/lt.23880
M3 - Article
C2 - 24692322
AN - SCOPUS:84903158574
SN - 1527-6465
VL - 20
SP - 791
EP - 797
JO - Liver Transplantation
JF - Liver Transplantation
IS - 7
ER -