TY - JOUR
T1 - Serum 25-hydroxyvitamin D and the incidence of atrial fibrillation
T2 - The Atherosclerosis Risk in Communities (ARIC) study
AU - Alonso, Alvaro
AU - Misialek, Jeffrey R.
AU - Michos, Erin D.
AU - Eckfeldt, John
AU - Selvin, Elizabeth
AU - Soliman, Elsayed Z.
AU - Chen, Lin Y.
AU - Gross, Myron D.
AU - Lutsey, Pamela L.
N1 - Funding Information:
The ARIC study is supported byNational Heart, Lung, and Blood Institute contracts (HHSN268201100005C, HHSN268201100006C, HHSN 268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN 268201100012C). Additional support was provided by grant R01HL103706 from the National Heart, Lung and Blood Institute to Dr Lutsey, an Administrative Supplement from the Office of Dietary Supplements to Dr Lutsey (R01HL103706-S1), and grant R01DK089174 from the National Institute of Diabetes and Digestive and Kidney Diseases to Dr Selvin. Dr Michos is supported by grant R01NS072243 from the National Institute of Neurological Disorders and Stroke
Publisher Copyright:
© 2016 Published on behalf of the European Society of Cardiology. All rights reserved.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Aims To assess the prospective association between circulating 25-hydroxyvitamin D [25(OH)D] and atrial fibrillation (AF) risk. Methods and results We studied 12 303 participants from the Atherosclerosis Risk in Communities study without baseline AF (1990-92). Baseline serum total 25(OH)D was measured using mass spectrometry. Incident AF cases were identified from electrocardiograms, hospital discharge codes, and death certificates through 2012. We estimated hazard ratios (HRs) and 95% confidence intervals (95% CIs) of AF across clinical categories of serum 25(OH)D concentrations with multivariable Cox models, and tested interactions by age, race, and sex. We meta-analysed our results with those from published prospective studies that reported associations between 25(OH)D and AF risk. During a median follow-up of 21 years, we identified 1866 AF events. In multivariable models, deficient 25(OH)D status (<20 ng/mL), compared with optimal levels (≥30 ng/mL), was not associated with AF risk (HR, 95% CI: 1.10, 0.96-1.26). A significant interaction of 25(OH)D concentrations with age (P = 0.01), but not with race or sex (P > 0.40), was identified, with higher risk of AF among those with deficient 25(OH)D status in younger (HR, 95% CI: 1.35, 1.05-1.73) but not older individuals (HR, 95% CI: 1.02, 0.86-1.21). A meta-analysis of these results and four prospective studies did not support a clinically relevant association of circulating 25(OH)D with AF risk [pooled HR, 95%CI: 1.04, 1.00-1.08, per 1 SD lower 25(OH)D]. Conclusion Low serum 25(OH)D was not associated with incident AF in a community-based cohort and in a meta-analysis of prospective studies. A possible association in younger individuals warrants further investigation.
AB - Aims To assess the prospective association between circulating 25-hydroxyvitamin D [25(OH)D] and atrial fibrillation (AF) risk. Methods and results We studied 12 303 participants from the Atherosclerosis Risk in Communities study without baseline AF (1990-92). Baseline serum total 25(OH)D was measured using mass spectrometry. Incident AF cases were identified from electrocardiograms, hospital discharge codes, and death certificates through 2012. We estimated hazard ratios (HRs) and 95% confidence intervals (95% CIs) of AF across clinical categories of serum 25(OH)D concentrations with multivariable Cox models, and tested interactions by age, race, and sex. We meta-analysed our results with those from published prospective studies that reported associations between 25(OH)D and AF risk. During a median follow-up of 21 years, we identified 1866 AF events. In multivariable models, deficient 25(OH)D status (<20 ng/mL), compared with optimal levels (≥30 ng/mL), was not associated with AF risk (HR, 95% CI: 1.10, 0.96-1.26). A significant interaction of 25(OH)D concentrations with age (P = 0.01), but not with race or sex (P > 0.40), was identified, with higher risk of AF among those with deficient 25(OH)D status in younger (HR, 95% CI: 1.35, 1.05-1.73) but not older individuals (HR, 95% CI: 1.02, 0.86-1.21). A meta-analysis of these results and four prospective studies did not support a clinically relevant association of circulating 25(OH)D with AF risk [pooled HR, 95%CI: 1.04, 1.00-1.08, per 1 SD lower 25(OH)D]. Conclusion Low serum 25(OH)D was not associated with incident AF in a community-based cohort and in a meta-analysis of prospective studies. A possible association in younger individuals warrants further investigation.
KW - Atrial fibrillation
KW - Cohort
KW - Epidemiology
KW - Meta-analysis
KW - Vitamin D
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U2 - 10.1093/europace/euv395
DO - 10.1093/europace/euv395
M3 - Article
C2 - 26847078
AN - SCOPUS:84982102706
SN - 1099-5129
VL - 18
SP - 1143
EP - 1149
JO - Europace
JF - Europace
IS - 8
ER -