TY - JOUR
T1 - Serum 25-hydroxyvitamin D and pulmonary function in older disabled community-dwelling women
AU - Semba, Richard D.
AU - Chang, Sandy S.
AU - Sun, Kai
AU - Cappola, Anne R.
AU - Ferrucci, Luigi
AU - Fried, Linda P.
N1 - Funding Information:
1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland. 2Section of Geriatrics, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut. 3Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia. 4Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland. 5Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
PY - 2012/6
Y1 - 2012/6
N2 - Background. Recent studies have expanded the functions of vitamin D to a possible role in pulmonary function. Our objective was to examine the relationship between serum 25-hydroxyvitamin D (25[OH]D), serum parathyroid hormone, and pulmonary function in older women.Methods.We examined the relationship of serum 25(OH)D and parathyroid hormone with pulmonary function (forced expiratory volume in one second [FEV1], forced vital capacity [FVC], and FEV1/FVC ratio) in a cross-sectional study of 646 moderately to severely disabled women, 65 years or more, living in the community in Baltimore, Maryland, who participated in the Women's Health and Aging Study I.Results.Overall, median (25th, 75th percentile) serum 25-hydroxyvitamin D concentrations were 19.9 (14.7, 26.7) ng/mL. Serum 25(OH)D was positively associated with FEV1 (p =. 03), FVC (p =. 18), and FEV1/FVC (p =. 04) in multivariable linear regression models adjusting for age, race, education, smoking, height, physical activity, cognition, interleukin-6, chronic diseases, and other potential confounders. In the same models, serum parathyroid hormone was not significantly associated with FEV1, FVC, or FEV 1/FVC.Conclusions.These findings support the idea that vitamin D deficiency is independently associated with poor pulmonary function in older disabled women.
AB - Background. Recent studies have expanded the functions of vitamin D to a possible role in pulmonary function. Our objective was to examine the relationship between serum 25-hydroxyvitamin D (25[OH]D), serum parathyroid hormone, and pulmonary function in older women.Methods.We examined the relationship of serum 25(OH)D and parathyroid hormone with pulmonary function (forced expiratory volume in one second [FEV1], forced vital capacity [FVC], and FEV1/FVC ratio) in a cross-sectional study of 646 moderately to severely disabled women, 65 years or more, living in the community in Baltimore, Maryland, who participated in the Women's Health and Aging Study I.Results.Overall, median (25th, 75th percentile) serum 25-hydroxyvitamin D concentrations were 19.9 (14.7, 26.7) ng/mL. Serum 25(OH)D was positively associated with FEV1 (p =. 03), FVC (p =. 18), and FEV1/FVC (p =. 04) in multivariable linear regression models adjusting for age, race, education, smoking, height, physical activity, cognition, interleukin-6, chronic diseases, and other potential confounders. In the same models, serum parathyroid hormone was not significantly associated with FEV1, FVC, or FEV 1/FVC.Conclusions.These findings support the idea that vitamin D deficiency is independently associated with poor pulmonary function in older disabled women.
KW - Aging
KW - Lung function
KW - Parathyroid hormone
KW - Vitamin D
KW - Women
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U2 - 10.1093/gerona/glr213
DO - 10.1093/gerona/glr213
M3 - Article
C2 - 22156439
AN - SCOPUS:84861075839
VL - 67 A
SP - 683
EP - 689
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
SN - 1079-5006
IS - 6
ER -