Serum α-tocopherol and γ-tocopherol concentrations and prostate cancer risk in the PLCO screening trial: A nested case-control study

Stephanie J. Weinstein, Ulrike Peters, Jiyoung Ahn, Marlin D. Friesen, Elio Riboli, Richard B. Hayes, Demetrius Albanes

Research output: Contribution to journalArticle

Abstract

Background: Vitamin E compounds exhibit prostate cancer preventive properties experimentally, but serologic investigations of tocopherols, and randomized controlled trials of supplementation in particular, have been inconsistent. Many studies suggest protective effects among smokers and for aggressive prostate cancer, however. Methods: We conducted a nested case-control study of serum α-tocopherol and γ-tocopherol and prostate cancer risk in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, with 680 prostate cancer cases and 824 frequency-matched controls. Multivariate-adjusted, conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs) for tocopherol quintiles. Results: Serum α-tocopherol and γ-tocopherol were inversely correlated (r = -0.24, p

Original languageEnglish (US)
Article numbere40204
JournalPLoS One
Volume7
Issue number7
DOIs
StatePublished - Jul 5 2012

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risk screening
Tocopherols
prostatic neoplasms
case-control studies
tocopherols
Case-Control Studies
Prostatic Neoplasms
Screening
Serum
Logistic Models
ovarian neoplasms
lung neoplasms
colorectal neoplasms
Vitamin E
Early Detection of Cancer
Ovarian Neoplasms
odds ratio
protective effect
vitamin E
Logistics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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Serum α-tocopherol and γ-tocopherol concentrations and prostate cancer risk in the PLCO screening trial : A nested case-control study. / Weinstein, Stephanie J.; Peters, Ulrike; Ahn, Jiyoung; Friesen, Marlin D.; Riboli, Elio; Hayes, Richard B.; Albanes, Demetrius.

In: PLoS One, Vol. 7, No. 7, e40204, 05.07.2012.

Research output: Contribution to journalArticle

Weinstein, Stephanie J. ; Peters, Ulrike ; Ahn, Jiyoung ; Friesen, Marlin D. ; Riboli, Elio ; Hayes, Richard B. ; Albanes, Demetrius. / Serum α-tocopherol and γ-tocopherol concentrations and prostate cancer risk in the PLCO screening trial : A nested case-control study. In: PLoS One. 2012 ; Vol. 7, No. 7.
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