SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer

Lindsey Enewold, Leah E. Mechanic, Elise D. Bowman, Elizabeth A Platz, Anthony J. Alberg

Research output: Contribution to journalArticle

Abstract

Background: Through their roles in tissue remodeling, variants in the genes that encode alpha1-antitrypsin (AAT) and neutrophil elastase (NE) were hypothesized to be associated with the risk of both chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC). Materials and Methods: Cases with prevalent COPD (n=145), incident NSCLC (n=203) or prevalent COPD plus NSCLC (n=118) were compared to disease-free controls (n=317), to assess two functional polymorphisms in serpin peptidase inhibitor, clade A, member 1 (SERPINA1), which encodes AAT, and eleven tagging polymorphisms in and around elastase 2 (ELA2), which encodes NE. All analyses were stratified by race. Results: Among African-Americans, the less efficient SERPINA1 variant appeared to be associated with increased risk of prevalent COPD but only in the presence of NSCLC (odds ratio=7.39; 95% confidence interval=1.03-53.21) and not after correcting for multiple comparisons. Conclusion: Variations in SERPINA1 and ELA2 were not consistently or strongly associated with the risk of either COPD or NSCLC in either race.

Original languageEnglish (US)
Pages (from-to)3923-3928
Number of pages6
JournalAnticancer Research
Volume32
Issue number9
StatePublished - Sep 2012

Fingerprint

Serpins
Protease Inhibitors
Non-Small Cell Lung Carcinoma
Chronic Obstructive Pulmonary Disease
Lung Neoplasms
Leukocyte Elastase
African Americans
Odds Ratio
pancreatic elastase II
Confidence Intervals
Genes

Keywords

  • Alpha1 antitrypsin
  • Case-control
  • Chronic bronchitis
  • Emphysema
  • Gene polymorphism
  • Lung cancer
  • Neutrophil elastase
  • SNPs

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Enewold, L., Mechanic, L. E., Bowman, E. D., Platz, E. A., & Alberg, A. J. (2012). SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer. Anticancer Research, 32(9), 3923-3928.

SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer. / Enewold, Lindsey; Mechanic, Leah E.; Bowman, Elise D.; Platz, Elizabeth A; Alberg, Anthony J.

In: Anticancer Research, Vol. 32, No. 9, 09.2012, p. 3923-3928.

Research output: Contribution to journalArticle

Enewold, L, Mechanic, LE, Bowman, ED, Platz, EA & Alberg, AJ 2012, 'SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer', Anticancer Research, vol. 32, no. 9, pp. 3923-3928.
Enewold L, Mechanic LE, Bowman ED, Platz EA, Alberg AJ. SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer. Anticancer Research. 2012 Sep;32(9):3923-3928.
Enewold, Lindsey ; Mechanic, Leah E. ; Bowman, Elise D. ; Platz, Elizabeth A ; Alberg, Anthony J. / SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer. In: Anticancer Research. 2012 ; Vol. 32, No. 9. pp. 3923-3928.
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