@article{24c49b234bca478e855e640e15e05bf6,
title = "Serpin-derived peptides are antiangiogenic and suppress breast tumor xenograft growth",
abstract = "Angiogenesis is the formation of neovasculature from preexisting microvessels. Several endogenous proteins regulate the balance of vessel formation and regression in the body including pigment epithelium-derived factor (PEDF), which has been shown to be antiangiogenic and to suppress tumor growth. Using sequence homology and bioinformatics, we previously identified several peptide sequences homologous to an active region of PEDF existing in multiple proteins in the human proteome. These short 11-mer peptides are found in a DEAH box helicase protein, CKIP-1 and caspase 10, and show similar activity in altering endothelial cell adhesion, migration and inducing apoptosis. We tested the peptide derived from DEAH box helicase protein in a triple-negative MDA-MB-231 breast orthotopic xenograft model in severe combined immunodeficient mice and show significant tumor suppression.",
author = "Koskimaki, {Jacob E.} and Rosca, {Elena V.} and Rivera, {Corban G.} and Esak Lee and William Chen and Pandey, {Niranjan B.} and Popel, {Aleksander S.}",
note = "Funding Information: Address all correspondence to: Jacob E. Koskimaki, BS, Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 613 Traylor Bldg, 720 Rutland Ave, Baltimore, MD 21205. E-mail: jkoskim1@jhmi.edu 1This work was supported by National Institutes of Health grants R21 CA152473 and R01 CA138264. Dr. Popel serves as the chief scientific officer of AsclepiX Therapeutics, LLC. The terms of this arrangement are being managed by the Johns Hopkins University in accordance with its conflict of interest policies. The other authors declare no conflict of interest. Received 16 August 2011; Revised 21 December 2011; Accepted 3 January 2012 Copyright {\textcopyright} 2012 Neoplasia Press, Inc. Open access under CC BY-NC-ND license. 1944-7124/12 DOI 10.1593/tlo.11244",
year = "2012",
month = apr,
doi = "10.1593/tlo.11244",
language = "English (US)",
volume = "5",
pages = "92--97",
journal = "Translational Oncology",
issn = "1936-5233",
publisher = "Neoplasia Press",
number = "2",
}