@inbook{37c9761b701a466d810ad970ab3c326d,
title = "Serotonin in cortical development: implications for autism spectrum disorder",
abstract = "Autism spectrum disorder (ASD) is a complex, multifaceted, developmental brain disorder that is based on behavioral criteria and is increasing in frequency. Despite decades of research, reliable biomarkers and effective therapeutic approaches remain elusive. Here we provide a focused review of research literature that suggests an involvement of the neurotransmitter serotonin (5-HT) in the etiology of the disorder. We describe the role that 5-HT plays in the maturation of brain structure and function as relevant to the neuropathologies of ASD. We discuss the role of 5-HT in autoimmune disorders, inflammation, and the gut–brain axis, all of which have been associated with ASD and are identified as risk factors for maternal transmission. Our review supports the hypothesis that the interplay of peripheral and central 5-HT levels in the mother and offspring, and placental 5-HT synthesis impacts early brain development in genetically vulnerable individuals and result in the neuropathologies associated with ASD.",
keywords = "Autism, Brain development, Environmental factors, Inflammation, Maternal risk factors, Serotonin",
author = "Hohmann, {Christine F.} and Lange, {Mary S.} and Blue, {Mary E.}",
note = "Funding Information: CH and ML were supported by ASCEND at MSU under NIGMS BUILD (linked awards RL5GM118972 and TL4GM118974). MEB was supported by NIH grants R01 HL091541, 1U54 HD079123, and R21NS10085. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
doi = "10.1016/B978-0-444-64125-0.00046-3",
language = "English (US)",
series = "Handbook of Behavioral Neuroscience",
publisher = "Elsevier B.V.",
pages = "901--922",
booktitle = "Handbook of Behavioral Neuroscience",
}