Abstract
This study assessed the effects of central serotonergic depletion on exploratory activity at baseline, as well as after administration of d-amphetamine or the anxiogenic β-carboline FG-7142. Intraventricular 5,7-dihydroxytryptamine (5,7-DHT) induced an almost complete depletion of serotonin [5-hydroxytryptamine (5-HT)] in the medial prefrontal cortex, nucleus accumbens, medial corpus striatum, and hippocampus with no changes in norepinephrine, dopamine or dihydroxyphenylacetic acid concentrations. 5-HT-depleted rats demonstrated reduced spontaneous and d-amphetamine-augmented exploration 3-10 weeks postoperatively. An effect on FG-7142-induced inhibition of exploratory activity was not apparent. These data implicate 5-HT systems in the expression of different aspects of exploratory and amphetamine-augmented motor behaviors.
Original language | English (US) |
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Pages (from-to) | 1247-1252 |
Number of pages | 6 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 43 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1992 |
Externally published | Yes |
Keywords
- 5,7-Dihydroxytryptamine
- Amphetamine
- Exploration
- FG-7142
- Locomotor activity
- Serotonin
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience