Serotonin depletion causes long-term reduction of exploration in the rat

Barbara K. Lipska, George E. Jaskiw, Alca Arya, Daniel Weinberger

Research output: Contribution to journalArticle

Abstract

This study assessed the effects of central serotonergic depletion on exploratory activity at baseline, as well as after administration of d-amphetamine or the anxiogenic β-carboline FG-7142. Intraventricular 5,7-dihydroxytryptamine (5,7-DHT) induced an almost complete depletion of serotonin [5-hydroxytryptamine (5-HT)] in the medial prefrontal cortex, nucleus accumbens, medial corpus striatum, and hippocampus with no changes in norepinephrine, dopamine or dihydroxyphenylacetic acid concentrations. 5-HT-depleted rats demonstrated reduced spontaneous and d-amphetamine-augmented exploration 3-10 weeks postoperatively. An effect on FG-7142-induced inhibition of exploratory activity was not apparent. These data implicate 5-HT systems in the expression of different aspects of exploratory and amphetamine-augmented motor behaviors.

Original languageEnglish (US)
Pages (from-to)1247-1252
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume43
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Rats
Serotonin
Dextroamphetamine
5,7-Dihydroxytryptamine
Corpus Striatum
Carbolines
Nucleus Accumbens
Amphetamine
Prefrontal Cortex
Hippocampus
Dopamine
Norepinephrine
Acids
FG 7142

Keywords

  • 5,7-Dihydroxytryptamine
  • Amphetamine
  • Exploration
  • FG-7142
  • Locomotor activity
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Serotonin depletion causes long-term reduction of exploration in the rat. / Lipska, Barbara K.; Jaskiw, George E.; Arya, Alca; Weinberger, Daniel.

In: Pharmacology, Biochemistry and Behavior, Vol. 43, No. 4, 1992, p. 1247-1252.

Research output: Contribution to journalArticle

Lipska, Barbara K. ; Jaskiw, George E. ; Arya, Alca ; Weinberger, Daniel. / Serotonin depletion causes long-term reduction of exploration in the rat. In: Pharmacology, Biochemistry and Behavior. 1992 ; Vol. 43, No. 4. pp. 1247-1252.
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