Serotonin depletion causes long-term reduction of exploration in the rat

Barbara K. Lipska, George E. Jaskiw, Alca Arya, Daniel R. Weinberger

Research output: Contribution to journalArticlepeer-review


This study assessed the effects of central serotonergic depletion on exploratory activity at baseline, as well as after administration of d-amphetamine or the anxiogenic β-carboline FG-7142. Intraventricular 5,7-dihydroxytryptamine (5,7-DHT) induced an almost complete depletion of serotonin [5-hydroxytryptamine (5-HT)] in the medial prefrontal cortex, nucleus accumbens, medial corpus striatum, and hippocampus with no changes in norepinephrine, dopamine or dihydroxyphenylacetic acid concentrations. 5-HT-depleted rats demonstrated reduced spontaneous and d-amphetamine-augmented exploration 3-10 weeks postoperatively. An effect on FG-7142-induced inhibition of exploratory activity was not apparent. These data implicate 5-HT systems in the expression of different aspects of exploratory and amphetamine-augmented motor behaviors.

Original languageEnglish (US)
Pages (from-to)1247-1252
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Issue number4
StatePublished - Dec 1992
Externally publishedYes


  • 5,7-Dihydroxytryptamine
  • Amphetamine
  • Exploration
  • FG-7142
  • Locomotor activity
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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