Serotonin 5HT1A receptor availability and pathological crying after stroke

M. Møller, G. Andersen, A. Gjedde

Research output: Contribution to journalArticle

Abstract

Objectives - Post-stroke depression and pathological crying (PC) implicate an imbalance of serotonergic neurotransmission. We claim that PC follows serotonin depletion that raises the binding potential (pB) of the 5-HT1A receptor antagonist [carbonyl-11C]WAY-100635, which is reversible by selective serotonin re-uptake inhibitor (SSRI) treatment. Materials and Methods - We PET scanned patients with acute stroke and PC and age-matched control subjects. Maps of receptor availability were generated from the images of eight cortical regions and raphe nuclei. Results - The maps showed highest binding in limbic areas and raphe nuclei, while binding in basal ganglia and cerebellum was negligible. Baseline binding potentials of patients were lower than that of control subjects (3.7 ± 0.6 vs 4.2 ± 0.2). Treatment with SSRI markedly reduced free receptor sites, whereas placebo administration led to a global increase. Discussion - The study is the first suggestion of changes of serotonergic neurotransmission in the early phase of stroke and the modulation of these changes with SSRI treatment.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalActa Neurologica Scandinavica
Volume116
Issue number2
DOIs
StatePublished - Aug 2007
Externally publishedYes

Fingerprint

Crying
Serotonin Receptors
Serotonin Uptake Inhibitors
Raphe Nuclei
Stroke
Synaptic Transmission
Serotonin 5-HT1 Receptor Antagonists
Receptor, Serotonin, 5-HT1A
Basal Ganglia
Cerebellum
Serotonin
Therapeutics
Placebos
Depression

Keywords

  • Pathological crying
  • Positron emission tomography
  • Selective serotonin re-uptake inhibitor
  • Serotonin receptor
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Serotonin 5HT1A receptor availability and pathological crying after stroke. / Møller, M.; Andersen, G.; Gjedde, A.

In: Acta Neurologica Scandinavica, Vol. 116, No. 2, 08.2007, p. 83-90.

Research output: Contribution to journalArticle

Møller, M. ; Andersen, G. ; Gjedde, A. / Serotonin 5HT1A receptor availability and pathological crying after stroke. In: Acta Neurologica Scandinavica. 2007 ; Vol. 116, No. 2. pp. 83-90.
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