Serotonin 5-HT2 receptor availability in chronic cocaine abusers

Gene Jack Wang; Nora D. Volkow; Jean Logon; Joanna S. Fowler; David Schlyer; Robert R. MacGregor; Robert J. Hitzemann; Albert Gjedde; Alfred P. Wolf

doi:10.1016/0024-3205(95)00090-9

Serotonin 5-HT₂ receptor availability in chronic cocaine abusers

Gene Jack Wang, Nora D. Volkow, Jean Logon, Joanna S. Fowler, David Schlyer, Robert R. MacGregor, Robert J. Hitzemann, Albert Gjedde, Alfred P. Wolf

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Serotonin 5-HT₂ receptor availability was evaluated in chronic cocaine abusers (n = 19) using positron emission tomography and F-18 N-methylspiperone and was compared to control subjects (n = 19). 5-HT₂ Receptor availability was measured in frontal, occipital, cingulate and orbitofrontal cortices using the ratio of the distribution volume in the region of interest to that in the cerebellum which is a function of B_max/K_d- 5-HT₂ Receptor availability was significantly higer in cingulate and orbitofrontal cortices than in other frontal regions or occipital cortex. The values were not different in normal subjects and cocaine abusers. These results did not show any changes in 5-HT₂ receptor availability in cocaine abusers as compared to the control subjects.

Original language	English (US)
Pages (from-to)	PL299-PL303
Journal	Life Sciences
Volume	56
Issue number	16
DOIs	https://doi.org/10.1016/0024-3205(95)00090-9
State	Published - Mar 10 1995

Keywords

chronic cocaine abuse
receptor availability
serotonin 5-HT

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.1016/0024-3205(95)00090-9

Cite this

@article{d940cece9e7f49f5bee6974ac15a961a,

title = "Serotonin 5-HT2 receptor availability in chronic cocaine abusers",

abstract = "Serotonin 5-HT2 receptor availability was evaluated in chronic cocaine abusers (n = 19) using positron emission tomography and F-18 N-methylspiperone and was compared to control subjects (n = 19). 5-HT2 Receptor availability was measured in frontal, occipital, cingulate and orbitofrontal cortices using the ratio of the distribution volume in the region of interest to that in the cerebellum which is a function of Bmax/Kd- 5-HT2 Receptor availability was significantly higer in cingulate and orbitofrontal cortices than in other frontal regions or occipital cortex. The values were not different in normal subjects and cocaine abusers. These results did not show any changes in 5-HT2 receptor availability in cocaine abusers as compared to the control subjects.",

keywords = "chronic cocaine abuse, receptor availability, serotonin 5-HT",

author = "Wang, {Gene Jack} and Volkow, {Nora D.} and Jean Logon and Fowler, {Joanna S.} and David Schlyer and MacGregor, {Robert R.} and Hitzemann, {Robert J.} and Albert Gjedde and Wolf, {Alfred P.}",

note = "Funding Information: This work wass upportebdy NIDA GrantN o. 5ROl-DA06891a ndb y U.S. Departmenotf Energy underc ontractD E-AC02-76CHO16. The authorst hankT . Johnson,P . King, N. Netusil,N . PappasC, . Redvanly,D . Warnerf or theirp articipationin variousa spectso f this work. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1995",

month = mar,

day = "10",

doi = "10.1016/0024-3205(95)00090-9",

language = "English (US)",

volume = "56",

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AU - Wang, Gene Jack

AU - Volkow, Nora D.

AU - Logon, Jean

AU - Fowler, Joanna S.

AU - Schlyer, David

AU - MacGregor, Robert R.

AU - Hitzemann, Robert J.

AU - Gjedde, Albert

AU - Wolf, Alfred P.

N1 - Funding Information: This work wass upportebdy NIDA GrantN o. 5ROl-DA06891a ndb y U.S. Departmenotf Energy underc ontractD E-AC02-76CHO16. The authorst hankT . Johnson,P . King, N. Netusil,N . PappasC, . Redvanly,D . Warnerf or theirp articipationin variousa spectso f this work. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1995/3/10

Y1 - 1995/3/10

N2 - Serotonin 5-HT2 receptor availability was evaluated in chronic cocaine abusers (n = 19) using positron emission tomography and F-18 N-methylspiperone and was compared to control subjects (n = 19). 5-HT2 Receptor availability was measured in frontal, occipital, cingulate and orbitofrontal cortices using the ratio of the distribution volume in the region of interest to that in the cerebellum which is a function of Bmax/Kd- 5-HT2 Receptor availability was significantly higer in cingulate and orbitofrontal cortices than in other frontal regions or occipital cortex. The values were not different in normal subjects and cocaine abusers. These results did not show any changes in 5-HT2 receptor availability in cocaine abusers as compared to the control subjects.

AB - Serotonin 5-HT2 receptor availability was evaluated in chronic cocaine abusers (n = 19) using positron emission tomography and F-18 N-methylspiperone and was compared to control subjects (n = 19). 5-HT2 Receptor availability was measured in frontal, occipital, cingulate and orbitofrontal cortices using the ratio of the distribution volume in the region of interest to that in the cerebellum which is a function of Bmax/Kd- 5-HT2 Receptor availability was significantly higer in cingulate and orbitofrontal cortices than in other frontal regions or occipital cortex. The values were not different in normal subjects and cocaine abusers. These results did not show any changes in 5-HT2 receptor availability in cocaine abusers as compared to the control subjects.

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KW - receptor availability

KW - serotonin 5-HT

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