Serotonin 5-HT2 receptor availability in chronic cocaine abusers

Gene Jack Wang, Nora D. Volkow, Jean Logon, Joanna S. Fowler, David Schlyer, Robert R. MacGregor, Robert J. Hitzemann, Albert Gjedde, Alfred P. Wolf

Research output: Contribution to journalArticle

Abstract

Serotonin 5-HT2 receptor availability was evaluated in chronic cocaine abusers (n = 19) using positron emission tomography and F-18 N-methylspiperone and was compared to control subjects (n = 19). 5-HT2 Receptor availability was measured in frontal, occipital, cingulate and orbitofrontal cortices using the ratio of the distribution volume in the region of interest to that in the cerebellum which is a function of Bmax/Kd- 5-HT2 Receptor availability was significantly higer in cingulate and orbitofrontal cortices than in other frontal regions or occipital cortex. The values were not different in normal subjects and cocaine abusers. These results did not show any changes in 5-HT2 receptor availability in cocaine abusers as compared to the control subjects.

Original languageEnglish (US)
JournalLife Sciences
Volume56
Issue number16
DOIs
StatePublished - Mar 10 1995
Externally publishedYes

Fingerprint

Serotonin 5-HT2 Receptors
Cocaine
Occipital Lobe
Gyrus Cinguli
Availability
Frontal Lobe
Prefrontal Cortex
Positron-Emission Tomography
Cerebellum
Positron emission tomography

Keywords

  • chronic cocaine abuse
  • receptor availability
  • serotonin 5-HT

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology

Cite this

Wang, G. J., Volkow, N. D., Logon, J., Fowler, J. S., Schlyer, D., MacGregor, R. R., ... Wolf, A. P. (1995). Serotonin 5-HT2 receptor availability in chronic cocaine abusers. Life Sciences, 56(16). https://doi.org/10.1016/0024-3205(95)00090-9

Serotonin 5-HT2 receptor availability in chronic cocaine abusers. / Wang, Gene Jack; Volkow, Nora D.; Logon, Jean; Fowler, Joanna S.; Schlyer, David; MacGregor, Robert R.; Hitzemann, Robert J.; Gjedde, Albert; Wolf, Alfred P.

In: Life Sciences, Vol. 56, No. 16, 10.03.1995.

Research output: Contribution to journalArticle

Wang, GJ, Volkow, ND, Logon, J, Fowler, JS, Schlyer, D, MacGregor, RR, Hitzemann, RJ, Gjedde, A & Wolf, AP 1995, 'Serotonin 5-HT2 receptor availability in chronic cocaine abusers', Life Sciences, vol. 56, no. 16. https://doi.org/10.1016/0024-3205(95)00090-9
Wang GJ, Volkow ND, Logon J, Fowler JS, Schlyer D, MacGregor RR et al. Serotonin 5-HT2 receptor availability in chronic cocaine abusers. Life Sciences. 1995 Mar 10;56(16). https://doi.org/10.1016/0024-3205(95)00090-9
Wang, Gene Jack ; Volkow, Nora D. ; Logon, Jean ; Fowler, Joanna S. ; Schlyer, David ; MacGregor, Robert R. ; Hitzemann, Robert J. ; Gjedde, Albert ; Wolf, Alfred P. / Serotonin 5-HT2 receptor availability in chronic cocaine abusers. In: Life Sciences. 1995 ; Vol. 56, No. 16.
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