Abstract
Background: The goal of this study was to examine serotonergic functioning and concomitant clinical and familial correlates in depressed abused children. Methods: L-5-Hydroxytryptophan (L-5-HTP) (0.8 mg/kg) was administered intravenously to 10 depressed abused (MDD-AB), 10 depressed nonabused (MDD-NA), and 10 normal control nonabused (NC-NA) children. The children in the two nonabused cohorts represent a small matched subset of children from a larger interlocking study of the psychobiology of depression. Blood samples for prolactin and cortisol were collected from 30 min before to 2.5 hours after L-5-HTP infusion. Results: The MDD-AB children secreted significantly more prolactin post-L-5-HTP than the children in the other two groups. There were no differences in baseline prolactin or any of the cortisol measures. Total prolactin post-L-5-HTP was significantly correlated with clinical ratings of aggressive behavior (rho=.48). In addition, children with a family history positive for suicide attempt (MDD-AB: n=7; MDD-NA: n=5; NC-NA: n=2) secreted significantly more prolactin post-L-5-HTP than children with no family history of suicide. Conclusions: Dysregulation in the serotonergic system in abused children appears to be related to both familial and experiential factors.
Original language | English (US) |
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Pages (from-to) | 973-981 |
Number of pages | 9 |
Journal | Biological psychiatry |
Volume | 44 |
Issue number | 10 |
DOIs | |
State | Published - Nov 15 1998 |
Externally published | Yes |
Keywords
- Child abuse
- Child depression
- Serotonin
ASJC Scopus subject areas
- Biological Psychiatry