Seroreactivity to hepatitis E virus in areas where the disease is not endemic

David L Thomas, Patrice O. Yarbough, David Vlahov, Sergei A. Tsarev, Kenrad Edwin Nelson, Alfred J. Saah, Robert H. Purcell

Research output: Contribution to journalArticle

Abstract

If the occurrence of hepatitis E virus antibody (anti-HEV) in regions where the disease is not endemic represents infection, rates may be greater in high-risk populations and behavioral correlates may reflect recognized transmission modes. Serum samples from 300 homosexual males, 300 injection drug users (IDUs), and 300 blood donors from Baltimore, Md., were tested for anti-HEV by enzyme immunoassay. Anti-HEV was found in an unexpectedly high percentage of homosexual men (15.9%) and IDUs (23.0%). However, anti-HEV was present in a similar proportion of blood donors (21.3%) (P > 0.05), while hepatitis A, B, and C virus antibodies were more prevalent in the high-risk groups (P <0.001). Among homosexual men, anti-HEV was not significantly correlated with a history of hepatitis, high-risk sexual practices, or sexually transmitted infections, in contrast to hepatitis A and B antibodies. Among IDUs, anti-HEV was not significantly associated with a history of hepatitis or high-risk drug-using practices, as was found with hepatitis C antibodies. In a setting without endemic hepatitis E disease, there was no evidence that anti-HEV reflected subclinical infection. Until the basis for HEV seroreactivity in such areas is elucidated, anti-HEV results should be interpreted with caution.

Original languageEnglish (US)
Pages (from-to)1244-1247
Number of pages4
JournalJournal of Clinical Microbiology
Volume35
Issue number5
StatePublished - May 1997

Fingerprint

Hepatitis E virus
Drug Users
Hepatitis A Antibodies
Hepatitis B Antibodies
Hepatitis C Antibodies
Blood Donors
Hepatitis
Injections
Hepatitis E
Baltimore
Asymptomatic Infections
Sexually Transmitted Diseases
Immunoenzyme Techniques
Anti-Idiotypic Antibodies
Infection
Serum
Pharmaceutical Preparations
Population
Sexual Minorities

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Thomas, D. L., Yarbough, P. O., Vlahov, D., Tsarev, S. A., Nelson, K. E., Saah, A. J., & Purcell, R. H. (1997). Seroreactivity to hepatitis E virus in areas where the disease is not endemic. Journal of Clinical Microbiology, 35(5), 1244-1247.

Seroreactivity to hepatitis E virus in areas where the disease is not endemic. / Thomas, David L; Yarbough, Patrice O.; Vlahov, David; Tsarev, Sergei A.; Nelson, Kenrad Edwin; Saah, Alfred J.; Purcell, Robert H.

In: Journal of Clinical Microbiology, Vol. 35, No. 5, 05.1997, p. 1244-1247.

Research output: Contribution to journalArticle

Thomas, DL, Yarbough, PO, Vlahov, D, Tsarev, SA, Nelson, KE, Saah, AJ & Purcell, RH 1997, 'Seroreactivity to hepatitis E virus in areas where the disease is not endemic', Journal of Clinical Microbiology, vol. 35, no. 5, pp. 1244-1247.
Thomas, David L ; Yarbough, Patrice O. ; Vlahov, David ; Tsarev, Sergei A. ; Nelson, Kenrad Edwin ; Saah, Alfred J. ; Purcell, Robert H. / Seroreactivity to hepatitis E virus in areas where the disease is not endemic. In: Journal of Clinical Microbiology. 1997 ; Vol. 35, No. 5. pp. 1244-1247.
@article{5c8b0d7b10df4135aa342ae0a6ebe63e,
title = "Seroreactivity to hepatitis E virus in areas where the disease is not endemic",
abstract = "If the occurrence of hepatitis E virus antibody (anti-HEV) in regions where the disease is not endemic represents infection, rates may be greater in high-risk populations and behavioral correlates may reflect recognized transmission modes. Serum samples from 300 homosexual males, 300 injection drug users (IDUs), and 300 blood donors from Baltimore, Md., were tested for anti-HEV by enzyme immunoassay. Anti-HEV was found in an unexpectedly high percentage of homosexual men (15.9{\%}) and IDUs (23.0{\%}). However, anti-HEV was present in a similar proportion of blood donors (21.3{\%}) (P > 0.05), while hepatitis A, B, and C virus antibodies were more prevalent in the high-risk groups (P <0.001). Among homosexual men, anti-HEV was not significantly correlated with a history of hepatitis, high-risk sexual practices, or sexually transmitted infections, in contrast to hepatitis A and B antibodies. Among IDUs, anti-HEV was not significantly associated with a history of hepatitis or high-risk drug-using practices, as was found with hepatitis C antibodies. In a setting without endemic hepatitis E disease, there was no evidence that anti-HEV reflected subclinical infection. Until the basis for HEV seroreactivity in such areas is elucidated, anti-HEV results should be interpreted with caution.",
author = "Thomas, {David L} and Yarbough, {Patrice O.} and David Vlahov and Tsarev, {Sergei A.} and Nelson, {Kenrad Edwin} and Saah, {Alfred J.} and Purcell, {Robert H.}",
year = "1997",
month = "5",
language = "English (US)",
volume = "35",
pages = "1244--1247",
journal = "Journal of Clinical Microbiology",
issn = "0095-1137",
publisher = "American Society for Microbiology",
number = "5",

}

TY - JOUR

T1 - Seroreactivity to hepatitis E virus in areas where the disease is not endemic

AU - Thomas, David L

AU - Yarbough, Patrice O.

AU - Vlahov, David

AU - Tsarev, Sergei A.

AU - Nelson, Kenrad Edwin

AU - Saah, Alfred J.

AU - Purcell, Robert H.

PY - 1997/5

Y1 - 1997/5

N2 - If the occurrence of hepatitis E virus antibody (anti-HEV) in regions where the disease is not endemic represents infection, rates may be greater in high-risk populations and behavioral correlates may reflect recognized transmission modes. Serum samples from 300 homosexual males, 300 injection drug users (IDUs), and 300 blood donors from Baltimore, Md., were tested for anti-HEV by enzyme immunoassay. Anti-HEV was found in an unexpectedly high percentage of homosexual men (15.9%) and IDUs (23.0%). However, anti-HEV was present in a similar proportion of blood donors (21.3%) (P > 0.05), while hepatitis A, B, and C virus antibodies were more prevalent in the high-risk groups (P <0.001). Among homosexual men, anti-HEV was not significantly correlated with a history of hepatitis, high-risk sexual practices, or sexually transmitted infections, in contrast to hepatitis A and B antibodies. Among IDUs, anti-HEV was not significantly associated with a history of hepatitis or high-risk drug-using practices, as was found with hepatitis C antibodies. In a setting without endemic hepatitis E disease, there was no evidence that anti-HEV reflected subclinical infection. Until the basis for HEV seroreactivity in such areas is elucidated, anti-HEV results should be interpreted with caution.

AB - If the occurrence of hepatitis E virus antibody (anti-HEV) in regions where the disease is not endemic represents infection, rates may be greater in high-risk populations and behavioral correlates may reflect recognized transmission modes. Serum samples from 300 homosexual males, 300 injection drug users (IDUs), and 300 blood donors from Baltimore, Md., were tested for anti-HEV by enzyme immunoassay. Anti-HEV was found in an unexpectedly high percentage of homosexual men (15.9%) and IDUs (23.0%). However, anti-HEV was present in a similar proportion of blood donors (21.3%) (P > 0.05), while hepatitis A, B, and C virus antibodies were more prevalent in the high-risk groups (P <0.001). Among homosexual men, anti-HEV was not significantly correlated with a history of hepatitis, high-risk sexual practices, or sexually transmitted infections, in contrast to hepatitis A and B antibodies. Among IDUs, anti-HEV was not significantly associated with a history of hepatitis or high-risk drug-using practices, as was found with hepatitis C antibodies. In a setting without endemic hepatitis E disease, there was no evidence that anti-HEV reflected subclinical infection. Until the basis for HEV seroreactivity in such areas is elucidated, anti-HEV results should be interpreted with caution.

UR - http://www.scopus.com/inward/record.url?scp=0030899128&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030899128&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 1244

EP - 1247

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 5

ER -