Seroprevalence of tularemia in rural Azerbaijan

Danielle V. Clark, Afrail Ismailov, Esmiralda Seyidova, Ayten Hajiyeva, Sevinj Bakhishova, Huseyn Hajiyev, Tahir Nuriyev, Saleh Piraliyev, Sadigulla Bagirov, Afag Aslanova, Amanda Debes, Maqsud Qasimov, Matthew J. Hepburn

Research output: Contribution to journalArticle

Abstract

A representative, two-stage probability sampling design was used to select 40 villages in northern Azerbaijan with populations of <500 people to screen for evidence of prior infection with Francisella tularensis. Informed consent was provided, and samples were obtained from 796 volunteers and tested for the presence of immunoglobulin G antibodies using enzyme-linked immunosorbent assay. F. tularensis seropositivity was prevalent (15.5% of volunteers), but there was minimal reporting of signs and symptoms consistent with clinical tularemia, suggesting that mild or asymptomatic infection commonly occurs. Frequently seeing rodents around the home was a risk factor for seropositivity (POR=1.6, p=0.03), controlling for age and gender. Geospatial analysis identified associations between village-level tularemia prevalence and suitable tick habitats, annual rainfall, precipitation in the driest quarter, and altitude. This study contributes to the growing understanding of the geographic distribution of tularemia and provides further information on the climatic and landscape conditions that increased the potential for exposure to this pathogen. The potential occurrence of asymptomatic or mild F. tularensis infection warrants further study.

Original languageEnglish (US)
Pages (from-to)558-563
Number of pages6
JournalVector-Borne and Zoonotic Diseases
Volume12
Issue number7
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

Fingerprint

Azerbaijan
Tularemia
Seroepidemiologic Studies
Volunteers
Francisella tularensis
Asymptomatic Infections
Ticks
Informed Consent
Signs and Symptoms
Ecosystem
Rodentia
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Antibodies
Population

Keywords

  • Azerbaijan
  • GIS
  • seroprevalence
  • tularemia

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology
  • Virology

Cite this

Clark, D. V., Ismailov, A., Seyidova, E., Hajiyeva, A., Bakhishova, S., Hajiyev, H., ... Hepburn, M. J. (2012). Seroprevalence of tularemia in rural Azerbaijan. Vector-Borne and Zoonotic Diseases, 12(7), 558-563. https://doi.org/10.1089/vbz.2010.0081

Seroprevalence of tularemia in rural Azerbaijan. / Clark, Danielle V.; Ismailov, Afrail; Seyidova, Esmiralda; Hajiyeva, Ayten; Bakhishova, Sevinj; Hajiyev, Huseyn; Nuriyev, Tahir; Piraliyev, Saleh; Bagirov, Sadigulla; Aslanova, Afag; Debes, Amanda; Qasimov, Maqsud; Hepburn, Matthew J.

In: Vector-Borne and Zoonotic Diseases, Vol. 12, No. 7, 01.07.2012, p. 558-563.

Research output: Contribution to journalArticle

Clark, DV, Ismailov, A, Seyidova, E, Hajiyeva, A, Bakhishova, S, Hajiyev, H, Nuriyev, T, Piraliyev, S, Bagirov, S, Aslanova, A, Debes, A, Qasimov, M & Hepburn, MJ 2012, 'Seroprevalence of tularemia in rural Azerbaijan', Vector-Borne and Zoonotic Diseases, vol. 12, no. 7, pp. 558-563. https://doi.org/10.1089/vbz.2010.0081
Clark DV, Ismailov A, Seyidova E, Hajiyeva A, Bakhishova S, Hajiyev H et al. Seroprevalence of tularemia in rural Azerbaijan. Vector-Borne and Zoonotic Diseases. 2012 Jul 1;12(7):558-563. https://doi.org/10.1089/vbz.2010.0081
Clark, Danielle V. ; Ismailov, Afrail ; Seyidova, Esmiralda ; Hajiyeva, Ayten ; Bakhishova, Sevinj ; Hajiyev, Huseyn ; Nuriyev, Tahir ; Piraliyev, Saleh ; Bagirov, Sadigulla ; Aslanova, Afag ; Debes, Amanda ; Qasimov, Maqsud ; Hepburn, Matthew J. / Seroprevalence of tularemia in rural Azerbaijan. In: Vector-Borne and Zoonotic Diseases. 2012 ; Vol. 12, No. 7. pp. 558-563.
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