Seroprevalence of HPV serotypes 6, 11, 16 and 18 in unvaccinated children from Mexico City

Reyna Lizette Pacheco-Domínguez, Ramón A. Durazo-Arvizu, Angélica López-Hernández, Jesica Figueroa-Padilla, Julia Berenice Ramírez-González, Malaquías López-Cervantes

Research output: Contribution to journalArticle

Abstract

Data regarding humoral immunity against HPV infection are scarce. Most analyses focus on the identification of viruses on mucous membranes and primarily refer to women of reproductive age. The aim of this work was to estimate the seroprevalence of antibodies against HPV serotypes 6, 11, 16 and 18 among unvaccinated boys living in Mexico City. A cross-sectional study of 257 male students from 48 public primary schools in Mexico City, whose ages fluctuated between 9 and 14 years, was carried out. Immunological status was assessed by applying the competitive Luminex Immunoassay of HPV (cLIA). Among the study population, we initially found that 38.52% (n = 99) of the children tested positive against one or more of the HPV 6, 11, 16 and/or 18 serotypes. The most commonly found serotype was isolated HPV 18 or in combination with other serotypes (22% and 31%, respectively), followed by HPV 6 with frequencies of 4.7% and 11%, respectively; however, lower frequencies were estimated for HPV 16 (2%; 6%) and isolated HPV 11, 4%. If a second set of cut-off points for seropositivity is applied, the overall prevalence for any serotype is reduced to 15.2%. As it appears that a significant sector of the study population has had basal contact with an HPV serotype, we recommend considering the possibility of vaccination against HPV at earlier ages.

Original languageEnglish (US)
Pages (from-to)e257
JournalEpidemiology and infection
Volume147
DOIs
StatePublished - Aug 30 2019
Externally publishedYes

Fingerprint

Human papillomavirus 6
Seroepidemiologic Studies
Mexico
Human papillomavirus 11
Human papillomavirus 18
Human papillomavirus 16
Humoral Immunity
Immunoassay
Population
Serogroup
Mucous Membrane
Vaccination
Cross-Sectional Studies
Students
Viruses
Antibodies
Infection

Keywords

  • Children
  • HPV
  • Mexico
  • preadolescents

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

Cite this

Pacheco-Domínguez, R. L., Durazo-Arvizu, R. A., López-Hernández, A., Figueroa-Padilla, J., Ramírez-González, J. B., & López-Cervantes, M. (2019). Seroprevalence of HPV serotypes 6, 11, 16 and 18 in unvaccinated children from Mexico City. Epidemiology and infection, 147, e257. https://doi.org/10.1017/S0950268819001341

Seroprevalence of HPV serotypes 6, 11, 16 and 18 in unvaccinated children from Mexico City. / Pacheco-Domínguez, Reyna Lizette; Durazo-Arvizu, Ramón A.; López-Hernández, Angélica; Figueroa-Padilla, Jesica; Ramírez-González, Julia Berenice; López-Cervantes, Malaquías.

In: Epidemiology and infection, Vol. 147, 30.08.2019, p. e257.

Research output: Contribution to journalArticle

Pacheco-Domínguez, RL, Durazo-Arvizu, RA, López-Hernández, A, Figueroa-Padilla, J, Ramírez-González, JB & López-Cervantes, M 2019, 'Seroprevalence of HPV serotypes 6, 11, 16 and 18 in unvaccinated children from Mexico City', Epidemiology and infection, vol. 147, pp. e257. https://doi.org/10.1017/S0950268819001341
Pacheco-Domínguez RL, Durazo-Arvizu RA, López-Hernández A, Figueroa-Padilla J, Ramírez-González JB, López-Cervantes M. Seroprevalence of HPV serotypes 6, 11, 16 and 18 in unvaccinated children from Mexico City. Epidemiology and infection. 2019 Aug 30;147:e257. https://doi.org/10.1017/S0950268819001341
Pacheco-Domínguez, Reyna Lizette ; Durazo-Arvizu, Ramón A. ; López-Hernández, Angélica ; Figueroa-Padilla, Jesica ; Ramírez-González, Julia Berenice ; López-Cervantes, Malaquías. / Seroprevalence of HPV serotypes 6, 11, 16 and 18 in unvaccinated children from Mexico City. In: Epidemiology and infection. 2019 ; Vol. 147. pp. e257.
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abstract = "Data regarding humoral immunity against HPV infection are scarce. Most analyses focus on the identification of viruses on mucous membranes and primarily refer to women of reproductive age. The aim of this work was to estimate the seroprevalence of antibodies against HPV serotypes 6, 11, 16 and 18 among unvaccinated boys living in Mexico City. A cross-sectional study of 257 male students from 48 public primary schools in Mexico City, whose ages fluctuated between 9 and 14 years, was carried out. Immunological status was assessed by applying the competitive Luminex Immunoassay of HPV (cLIA). Among the study population, we initially found that 38.52{\%} (n = 99) of the children tested positive against one or more of the HPV 6, 11, 16 and/or 18 serotypes. The most commonly found serotype was isolated HPV 18 or in combination with other serotypes (22{\%} and 31{\%}, respectively), followed by HPV 6 with frequencies of 4.7{\%} and 11{\%}, respectively; however, lower frequencies were estimated for HPV 16 (2{\%}; 6{\%}) and isolated HPV 11, 4{\%}. If a second set of cut-off points for seropositivity is applied, the overall prevalence for any serotype is reduced to 15.2{\%}. As it appears that a significant sector of the study population has had basal contact with an HPV serotype, we recommend considering the possibility of vaccination against HPV at earlier ages.",
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