TY - JOUR
T1 - Seroprevalence of helicobacter Pylori infections in Thailand
AU - Perez-Perez, Guillermo I.
AU - Thylor, David N.
AU - Bodhidatta, Ladapom
AU - Wongsrichanalai, Jirasak
AU - Baze, Wallace B.
AU - Dunn, Bruce E.
AU - Echeverria, Peter D.
AU - Blaser, Martin J.
N1 - Funding Information:
Received 13 October 1989; revised 18 December 1989. Financial support: Medical Research Service of the Veterans Administration, an interagency agreement with the US Army Medical Research and Development Command, and Procter and Gamble. M. J. B. is a Clinical Investigator of the Veterans Administration. Reprints and correspondence: Dr. Guillermo I. Perez-Perez, Division of Infectious Diseases, Department of Medicine, Vanderbilt University, Nashville, TN 37232-2605. * Present addresses: Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN (G. I. P.-P., M. 1. B.); Laboratory of Microbiology,John L. McClellan Memorial VeteransHospital, Little Rock, AR (B. E. D.).
PY - 1990/6
Y1 - 1990/6
N2 - Serologic studies in developed countries indicate that Helicobacter (formerly Campylobacter) pylori infection is uncommon until the third decade of life and achieves a peak prevalence of 50% in the seventh decade. In developing countries the epidemiology of H. pylori has not well been described. A sensitive and specific serologic assay for H. pylori infection was validated in Thai patients alsostudied by culture and histologic examination of biopsy specimens. The prevalence of H. pylori antibodies in persons from a rural Thai community began early (17.5%of children 5-9 years old), increased to 55% during the third decade of life, and peaked (75%) in the 30- to 49-year age group. At a Bangkok orphanage where enteric infections are hyperendemic, 74% of children 1-4 years old were seropositive. This study shows that the prevalence of H. pylori infection in Thailand is higher than in industrialized countries. The high infection rate at the orphanage suggests that person-to-person transmission of H. pylori may be occurring.
AB - Serologic studies in developed countries indicate that Helicobacter (formerly Campylobacter) pylori infection is uncommon until the third decade of life and achieves a peak prevalence of 50% in the seventh decade. In developing countries the epidemiology of H. pylori has not well been described. A sensitive and specific serologic assay for H. pylori infection was validated in Thai patients alsostudied by culture and histologic examination of biopsy specimens. The prevalence of H. pylori antibodies in persons from a rural Thai community began early (17.5%of children 5-9 years old), increased to 55% during the third decade of life, and peaked (75%) in the 30- to 49-year age group. At a Bangkok orphanage where enteric infections are hyperendemic, 74% of children 1-4 years old were seropositive. This study shows that the prevalence of H. pylori infection in Thailand is higher than in industrialized countries. The high infection rate at the orphanage suggests that person-to-person transmission of H. pylori may be occurring.
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U2 - 10.1093/infdis/161.6.1237
DO - 10.1093/infdis/161.6.1237
M3 - Article
C2 - 2345304
AN - SCOPUS:0025325462
VL - 161
SP - 1237
EP - 1241
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 6
ER -