Seroprevalence of Antibodies against Highly Pathogenic Avian Influenza A (H5N1) Virus among Poultry Workers in Bangladesh, 2009

Sharifa Nasreen, Salah Uddin Khan, Eduardo Azziz-Baumgartner, Kathy Hancock, Vic Veguilla, David Wang, Mahmudur Rahman, A. S.M. Alamgir, Katharine Sturm-Ramirez, Emily Gurley, Stephen P. Luby, Jacqueline M. Katz, Timothy M. Uyeki

Research output: Contribution to journalArticle

Abstract

We conducted a cross-sectional study in 2009 to determine the seroprevalence and risk factors for highly pathogenic avian influenza A (H5N1) [HPAI H5N1] virus antibodies among poultry workers at farms and live bird markets with confirmed/suspected poultry outbreaks during 2009 in Bangladesh. We tested sera by microneutralization assay using A/Bangladesh/207095/2008 (H5N1; clade 2.2.2) virus with confirmation by horse red blood cell hemagglutination inhibition and H5-specific Western blot assays. We enrolled 212 workers from 87 farms and 210 workers from three live bird markets. One hundred and two farm workers (48%) culled poultry. One hundred and ninety-three farm workers (91%) and 178 market workers (85%) reported direct contact with poultry that died during a laboratory confirmed HPAI H5N1 poultry farm outbreak or market poultry die-offs from suspected HPAI H5N1. Despite exposure to sick poultry, no farm or market poultry workers were seropositive for HPAI H5N1 virus antibodies (95% confidence interval 0-1%).

Original languageEnglish (US)
Article numbere73200
JournalPLoS One
Volume8
Issue number9
DOIs
StatePublished - Sep 5 2013
Externally publishedYes

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H5N1 Subtype Influenza A Virus
Poultry
Influenza in Birds
Bangladesh
Influenza A virus
Seroepidemiologic Studies
avian influenza
Viruses
seroprevalence
poultry
Farms
antibodies
Antibodies
markets
farms
farm labor
Birds
Disease Outbreaks
Assays
birds

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Nasreen, S., Uddin Khan, S., Azziz-Baumgartner, E., Hancock, K., Veguilla, V., Wang, D., ... Uyeki, T. M. (2013). Seroprevalence of Antibodies against Highly Pathogenic Avian Influenza A (H5N1) Virus among Poultry Workers in Bangladesh, 2009. PLoS One, 8(9), [e73200]. https://doi.org/10.1371/journal.pone.0073200

Seroprevalence of Antibodies against Highly Pathogenic Avian Influenza A (H5N1) Virus among Poultry Workers in Bangladesh, 2009. / Nasreen, Sharifa; Uddin Khan, Salah; Azziz-Baumgartner, Eduardo; Hancock, Kathy; Veguilla, Vic; Wang, David; Rahman, Mahmudur; Alamgir, A. S.M.; Sturm-Ramirez, Katharine; Gurley, Emily; Luby, Stephen P.; Katz, Jacqueline M.; Uyeki, Timothy M.

In: PLoS One, Vol. 8, No. 9, e73200, 05.09.2013.

Research output: Contribution to journalArticle

Nasreen, S, Uddin Khan, S, Azziz-Baumgartner, E, Hancock, K, Veguilla, V, Wang, D, Rahman, M, Alamgir, ASM, Sturm-Ramirez, K, Gurley, E, Luby, SP, Katz, JM & Uyeki, TM 2013, 'Seroprevalence of Antibodies against Highly Pathogenic Avian Influenza A (H5N1) Virus among Poultry Workers in Bangladesh, 2009', PLoS One, vol. 8, no. 9, e73200. https://doi.org/10.1371/journal.pone.0073200
Nasreen, Sharifa ; Uddin Khan, Salah ; Azziz-Baumgartner, Eduardo ; Hancock, Kathy ; Veguilla, Vic ; Wang, David ; Rahman, Mahmudur ; Alamgir, A. S.M. ; Sturm-Ramirez, Katharine ; Gurley, Emily ; Luby, Stephen P. ; Katz, Jacqueline M. ; Uyeki, Timothy M. / Seroprevalence of Antibodies against Highly Pathogenic Avian Influenza A (H5N1) Virus among Poultry Workers in Bangladesh, 2009. In: PLoS One. 2013 ; Vol. 8, No. 9.
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