TY - JOUR
T1 - Seroprevalence for hepatitis e and other viral hepatitides among diverse populations, Malawi
AU - Taha, Taha E.
AU - Rusie, Laura K.
AU - Labrique, Alain
AU - Nyirenda, Mulinda
AU - Soko, Dean
AU - Kamanga, Melvin
AU - Kumwenda, Johnstone
AU - Farazadegan, Homayoon
AU - Nelson, Kenrad
AU - Kumwenda, Newton
N1 - Publisher Copyright:
© 2015, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2015
Y1 - 2015
N2 - Data on prevalence of hepatitis E virus (HEV) in Malawi is limited. We tested blood samples from HIV-uninfected and -infected populations of women and men enrolled in research studies in Malawi during 1989–2008 to determine the seroprevalence of HEV, hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV). Samples were tested for IgG against HEV, total antibodies against HAV and HCV, and presence of HBV surface antigens. Of 800 samples tested, 16.5% were positive for HEV IgG, 99.6% were positive for HAV antibodies, 7.5% were positive for HBV surface antigen, and 7.1% were positive for HCV antibodies. No clear trends over time were observed in the seroprevalence of HEV, and HIV status was not associated with hepatitis seroprevalence. These preliminary data suggest that the seroprevalence of HEV is high in Malawi; the clinical effects may be unrecognized or routinely misclassified.
AB - Data on prevalence of hepatitis E virus (HEV) in Malawi is limited. We tested blood samples from HIV-uninfected and -infected populations of women and men enrolled in research studies in Malawi during 1989–2008 to determine the seroprevalence of HEV, hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV). Samples were tested for IgG against HEV, total antibodies against HAV and HCV, and presence of HBV surface antigens. Of 800 samples tested, 16.5% were positive for HEV IgG, 99.6% were positive for HAV antibodies, 7.5% were positive for HBV surface antigen, and 7.1% were positive for HCV antibodies. No clear trends over time were observed in the seroprevalence of HEV, and HIV status was not associated with hepatitis seroprevalence. These preliminary data suggest that the seroprevalence of HEV is high in Malawi; the clinical effects may be unrecognized or routinely misclassified.
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U2 - 10.3201/eid2107.141748
DO - 10.3201/eid2107.141748
M3 - Article
C2 - 26079666
AN - SCOPUS:84931420162
SN - 1080-6040
VL - 21
SP - 1174
EP - 1182
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 7
ER -