Seroprevalence for hepatitis e and other viral hepatitides among diverse populations, Malawi

Taha E. Taha, Laura K. Rusie, Alain Labrique, Mulinda Nyirenda, Dean Soko, Melvin Kamanga, Johnstone Kumwenda, Homayoon Farazadegan, Kenrad Nelson, Newton Kumwenda

Research output: Contribution to journalArticle

Abstract

Data on prevalence of hepatitis E virus (HEV) in Malawi is limited. We tested blood samples from HIV-uninfected and -infected populations of women and men enrolled in research studies in Malawi during 1989–2008 to determine the seroprevalence of HEV, hepatitis A virus (HAV), hepa­titis B virus (HBV), and hepatitis C virus (HCV). Samples were tested for IgG against HEV, total antibodies against HAV and HCV, and presence of HBV surface antigens. Of 800 samples tested, 16.5% were positive for HEV IgG, 99.6% were positive for HAV antibodies, 7.5% were posi­tive for HBV surface antigen, and 7.1% were positive for HCV antibodies. No clear trends over time were observed in the seroprevalence of HEV, and HIV status was not as­sociated with hepatitis seroprevalence. These preliminary data suggest that the seroprevalence of HEV is high in Malawi; the clinical effects may be unrecognized or rou­tinely misclassified.

Original languageEnglish (US)
Pages (from-to)1174-1182
Number of pages9
JournalEmerging infectious diseases
Volume21
Issue number7
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Seroprevalence for hepatitis e and other viral hepatitides among diverse populations, Malawi'. Together they form a unique fingerprint.

  • Cite this