Seroprevalence and correlates of herpes simplex virus type 2 infection in five sexually transmitted-disease clinics

Sami L. Gottlieb; John M. Douglas; D. Scott Schmid; Gail Bolan; Michael Iatesta; C. Kevin Malotte; Jonathan Zenilman; Mark Foster; Anna E. Barón; John F. Steiner; Thomas A. Peterman; Mary L. Kamb; John M.Douglas Hoxworth; Tamara Hoxworth; Ken Miller; William McGill; Ruth Bundy; Laura A. Hoyt; C. Kevin Malotte; Fen Rhodes; Michael Iatesta; Eileen Napolitano; Judy Rogers; Ken Spitalny; Gail A. Bolan; Coleen LeDrew; Kimberly A.J. Coleman; Luna Hananel; Charlotte K. Kent; Robert Francis; Christopher Gordon; Nancy Rosenshine; Carmita Signes

doi:10.1086/344317

Seroprevalence and correlates of herpes simplex virus type 2 infection in five sexually transmitted-disease clinics

Sami L. Gottlieb, John M. Douglas, D. Scott Schmid, Gail Bolan, Michael Iatesta, C. Kevin Malotte, Jonathan Zenilman, Mark Foster, Anna E. Barón, John F. Steiner, Thomas A. Peterman, Mary L. Kamb, John M.Douglas Hoxworth, Tamara Hoxworth, Ken Miller, William McGill, Ruth Bundy, Laura A. Hoyt, C. Kevin Malotte, Fen RhodesMichael Iatesta, Eileen Napolitano, Judy Rogers, Ken Spitalny, Gail A. Bolan, Coleen LeDrew, Kimberly A.J. Coleman, Luna Hananel, Charlotte K. Kent, Robert Francis, Christopher Gordon, Nancy Rosenshine, Carmita Signes

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

The seroprevalence of herpes simplex virus type 2 (HSV-2) infection was studied among 4128 patients from sexually transmitted disease (STD) clinics who were enrolled in a randomized controlled trial of human immunodeficiency virus and STD counseling efficacy. HSV-2 seroprevalence was 40.8% and was higher in women than in men (52.0% vs. 32.4%; P <.0001) and higher in blacks than in nonblacks (48.1% vs. 29.6%; P <.0001). Among 14-19-year-old patients, 36.8% of black women and 25.8% of nonblack women were infected with HSV-2. Independent predictors of HSV-2 seropositivity included female sex, black race, older age, less education, more lifetime sex partners, prior diagnosis of syphilis or gonorrhea, and lack of HSV-1 antibody. The majority of HSV-2-seropositive persons (84.7%) had never received a diagnosis of genital herpes. HSV-2 infection is common in STD clinic attendees in the United States, even among young age groups, especially among women. Efforts to prevent genital herpes should begin at an early age. The high rate of undiagnosed HSV-2 infection likely contributes to ongoing transmission.

Original language	English (US)
Pages (from-to)	1381-1389
Number of pages	9
Journal	Journal of Infectious Diseases
Volume	186
Issue number	10
DOIs	https://doi.org/10.1086/344317
State	Published - Nov 15 2002
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Access to Document

10.1086/344317

Cite this

Gottlieb, S. L., Douglas, J. M., Schmid, D. S., Bolan, G., Iatesta, M., Malotte, C. K., Zenilman, J., Foster, M., Barón, A. E., Steiner, J. F., Peterman, T. A., Kamb, M. L., Hoxworth, J. M. D., Hoxworth, T., Miller, K., McGill, W., Bundy, R., Hoyt, L. A., Malotte, C. K., ... Signes, C. (2002). Seroprevalence and correlates of herpes simplex virus type 2 infection in five sexually transmitted-disease clinics. Journal of Infectious Diseases, 186(10), 1381-1389. https://doi.org/10.1086/344317

Gottlieb, SL, Douglas, JM, Schmid, DS, Bolan, G, Iatesta, M, Malotte, CK, Zenilman, J, Foster, M, Barón, AE, Steiner, JF, Peterman, TA, Kamb, ML, Hoxworth, JMD, Hoxworth, T, Miller, K, McGill, W, Bundy, R, Hoyt, LA, Malotte, CK, Rhodes, F, Iatesta, M, Napolitano, E, Rogers, J, Spitalny, K, Bolan, GA, LeDrew, C, Coleman, KAJ, Hananel, L, Kent, CK, Francis, R, Gordon, C, Rosenshine, N & Signes, C 2002, 'Seroprevalence and correlates of herpes simplex virus type 2 infection in five sexually transmitted-disease clinics', Journal of Infectious Diseases, vol. 186, no. 10, pp. 1381-1389. https://doi.org/10.1086/344317

@article{513e76c9df374ae9a4d367765517a9f0,

title = "Seroprevalence and correlates of herpes simplex virus type 2 infection in five sexually transmitted-disease clinics",

abstract = "The seroprevalence of herpes simplex virus type 2 (HSV-2) infection was studied among 4128 patients from sexually transmitted disease (STD) clinics who were enrolled in a randomized controlled trial of human immunodeficiency virus and STD counseling efficacy. HSV-2 seroprevalence was 40.8% and was higher in women than in men (52.0% vs. 32.4%; P <.0001) and higher in blacks than in nonblacks (48.1% vs. 29.6%; P <.0001). Among 14-19-year-old patients, 36.8% of black women and 25.8% of nonblack women were infected with HSV-2. Independent predictors of HSV-2 seropositivity included female sex, black race, older age, less education, more lifetime sex partners, prior diagnosis of syphilis or gonorrhea, and lack of HSV-1 antibody. The majority of HSV-2-seropositive persons (84.7%) had never received a diagnosis of genital herpes. HSV-2 infection is common in STD clinic attendees in the United States, even among young age groups, especially among women. Efforts to prevent genital herpes should begin at an early age. The high rate of undiagnosed HSV-2 infection likely contributes to ongoing transmission.",

author = "Gottlieb, {Sami L.} and Douglas, {John M.} and Schmid, {D. Scott} and Gail Bolan and Michael Iatesta and Malotte, {C. Kevin} and Jonathan Zenilman and Mark Foster and Bar{\'o}n, {Anna E.} and Steiner, {John F.} and Peterman, {Thomas A.} and Kamb, {Mary L.} and Hoxworth, {John M.Douglas} and Tamara Hoxworth and Ken Miller and William McGill and Ruth Bundy and Hoyt, {Laura A.} and Malotte, {C. Kevin} and Fen Rhodes and Michael Iatesta and Eileen Napolitano and Judy Rogers and Ken Spitalny and Bolan, {Gail A.} and Coleen LeDrew and Coleman, {Kimberly A.J.} and Luna Hananel and Kent, {Charlotte K.} and Robert Francis and Christopher Gordon and Nancy Rosenshine and Carmita Signes",

note = "Funding Information: Financial support: National Research Service Award grant 5 T32 PE10006 08; cooperative agreements with state and local health departments and the Centers for Disease Control and Prevention, National Center for HIV, STD, and TB Prevention.",

year = "2002",

month = nov,

day = "15",

doi = "10.1086/344317",

language = "English (US)",

volume = "186",

pages = "1381--1389",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "10",

}

TY - JOUR

T1 - Seroprevalence and correlates of herpes simplex virus type 2 infection in five sexually transmitted-disease clinics

AU - Gottlieb, Sami L.

AU - Douglas, John M.

AU - Schmid, D. Scott

AU - Bolan, Gail

AU - Iatesta, Michael

AU - Malotte, C. Kevin

AU - Zenilman, Jonathan

AU - Foster, Mark

AU - Barón, Anna E.

AU - Steiner, John F.

AU - Peterman, Thomas A.

AU - Kamb, Mary L.

AU - Hoxworth, John M.Douglas

AU - Hoxworth, Tamara

AU - Miller, Ken

AU - McGill, William

AU - Bundy, Ruth

AU - Hoyt, Laura A.

AU - Malotte, C. Kevin

AU - Rhodes, Fen

AU - Iatesta, Michael

AU - Napolitano, Eileen

AU - Rogers, Judy

AU - Spitalny, Ken

AU - Bolan, Gail A.

AU - LeDrew, Coleen

AU - Coleman, Kimberly A.J.

AU - Hananel, Luna

AU - Kent, Charlotte K.

AU - Francis, Robert

AU - Gordon, Christopher

AU - Rosenshine, Nancy

AU - Signes, Carmita

N1 - Funding Information: Financial support: National Research Service Award grant 5 T32 PE10006 08; cooperative agreements with state and local health departments and the Centers for Disease Control and Prevention, National Center for HIV, STD, and TB Prevention.

PY - 2002/11/15

Y1 - 2002/11/15

N2 - The seroprevalence of herpes simplex virus type 2 (HSV-2) infection was studied among 4128 patients from sexually transmitted disease (STD) clinics who were enrolled in a randomized controlled trial of human immunodeficiency virus and STD counseling efficacy. HSV-2 seroprevalence was 40.8% and was higher in women than in men (52.0% vs. 32.4%; P <.0001) and higher in blacks than in nonblacks (48.1% vs. 29.6%; P <.0001). Among 14-19-year-old patients, 36.8% of black women and 25.8% of nonblack women were infected with HSV-2. Independent predictors of HSV-2 seropositivity included female sex, black race, older age, less education, more lifetime sex partners, prior diagnosis of syphilis or gonorrhea, and lack of HSV-1 antibody. The majority of HSV-2-seropositive persons (84.7%) had never received a diagnosis of genital herpes. HSV-2 infection is common in STD clinic attendees in the United States, even among young age groups, especially among women. Efforts to prevent genital herpes should begin at an early age. The high rate of undiagnosed HSV-2 infection likely contributes to ongoing transmission.

AB - The seroprevalence of herpes simplex virus type 2 (HSV-2) infection was studied among 4128 patients from sexually transmitted disease (STD) clinics who were enrolled in a randomized controlled trial of human immunodeficiency virus and STD counseling efficacy. HSV-2 seroprevalence was 40.8% and was higher in women than in men (52.0% vs. 32.4%; P <.0001) and higher in blacks than in nonblacks (48.1% vs. 29.6%; P <.0001). Among 14-19-year-old patients, 36.8% of black women and 25.8% of nonblack women were infected with HSV-2. Independent predictors of HSV-2 seropositivity included female sex, black race, older age, less education, more lifetime sex partners, prior diagnosis of syphilis or gonorrhea, and lack of HSV-1 antibody. The majority of HSV-2-seropositive persons (84.7%) had never received a diagnosis of genital herpes. HSV-2 infection is common in STD clinic attendees in the United States, even among young age groups, especially among women. Efforts to prevent genital herpes should begin at an early age. The high rate of undiagnosed HSV-2 infection likely contributes to ongoing transmission.

UR - http://www.scopus.com/inward/record.url?scp=0037111024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037111024&partnerID=8YFLogxK

U2 - 10.1086/344317

DO - 10.1086/344317

M3 - Article

C2 - 12404152

AN - SCOPUS:0037111024

SN - 0022-1899

VL - 186

SP - 1381

EP - 1389

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 10

ER -

Seroprevalence and correlates of herpes simplex virus type 2 infection in five sexually transmitted-disease clinics

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this